6308-19-6Relevant articles and documents
Carboxy Dioxolanes as Systems for Chemical Protection and Controlled Release of Volatile Aldehydes
Gavina, Pablo,Lavernia, Natividad Lopez,Mestres, Ramon,Munoz, Elena
, p. 1533 - 1553 (2007/10/03)
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Percutaneous absorption enhancers, compositions containing same and method of use
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, (2008/06/13)
Novel 1,3-dioxolanes (1,3-dioxyacyclopentanes) are provided along with new 1,3-dioxolanes (1,3-dioxacyclopentanes) compositions which are useful in enhancing the absorption of therapeutic agents through the skin of humans and animals. The method for enhancing skin penetration of therapeutic agents using 1,3-dioxacycloalkanes is also described. The preferred compounds are 1,3-dioxolanes (1,3-dioxacyclopentanes) and 1,3-dioxanes (1,3-dioxacyclohexanes). The preferred compounds have the formula: STR1 wherein R, R0, R1, R2, R3, R4, R5 and R6 are each independently selected from hydrogen and C1 to C18 aliphatic groups, preferably alkyl, alkenyl, and the halo, hydroxy, carboxy, carboxamide and carboalkoxy substituted forms thereof, with at least one of said R's an alkyl or alkenyl group of C4 to C18 and n=0 or 1; the total number of carbon atoms in all of said R groups being no more than 40, and preferably less than 20 and not more than 1 thereof containing 18 or more carbon atoms.