63107-40-4 Usage
Uses
Used in Pharmaceutical Industry:
S-(2-boronoethyl)-L-cysteine is used as a research compound for studying the role of arginase enzymes in various diseases. Its ability to inhibit arginase I and II makes it a potential therapeutic agent for conditions where arginase activity is implicated, such as cancer and inflammatory disorders.
Used in Medical Research:
S-(2-boronoethyl)-L-cysteine is used as a tool in medical research to investigate the effects of arginase inhibition on nitric oxide production and other biological processes. By inhibiting arginase, BEC can modulate the balance between nitric oxide and polyamines, which are important for cell growth and proliferation.
Used in Drug Development:
S-(2-boronoethyl)-L-cysteine is used as a lead compound in the development of new drugs targeting arginase enzymes. Its high potency and selectivity for arginase make it a promising candidate for the treatment of diseases where arginase activity contributes to their progression.
Used in Biochemical Assays:
S-(2-boronoethyl)-L-cysteine is used as a reagent in biochemical assays to measure arginase activity. Its slow-binding competitive inhibition allows for accurate determination of arginase activity in biological samples, aiding in the study of arginase function and regulation.
Biochem/physiol Actions
BEC (S-(2-boronoethyl)-l-cysteine) is a potent and specific arginase inhibitor that restores flow-induced responses in arterioles from diabetic rats.
Enzyme inhibitor
This boronic acid-containing arginine analogue (FW = 190.00 g/mol; CAS 63107-40-4; Abbreviation: BEC) is a slow, tight-binding competitive inhibitor of arginase (Reaction: L-Arginine + H2O ? Urea + L-Ornithine), the binuclear manganese metalloenzyme catalyzing the last step in the Urea Cycle. Upon binding, the boronic acid moiety undergoes nucleophilic attack by the enzyme’s metal-bridging hydroxide ion, yielding a tetrahedral boronate anion that bridges the binuclear manganese cluster and mimics the tetrahedral intermediate (or a flanking transition state configuration) in arginase catalysis. BEC is also a potent inhibitor of human arginase II with Ki values of 0.31 μM and 30 nM at pH 7.5 and 9.5, respectively. Inhibition of arginase by BEC increases the circulating concentration of arginine, thereby increasing nitric oxide synthesis and significantly enhancing NO-dependent smooth muscle relaxation in human penile corpus cavernosum. Arginase is thus a potential druggable target for the treatment of erectile dysfunction.
Check Digit Verification of cas no
The CAS Registry Mumber 63107-40-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,1,0 and 7 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 63107-40:
(7*6)+(6*3)+(5*1)+(4*0)+(3*7)+(2*4)+(1*0)=94
94 % 10 = 4
So 63107-40-4 is a valid CAS Registry Number.
