6311-79-1

Usage

Uses

Used in Pharmaceutical Industry:
4,6-bis(methylsulfanyl)pyrimidin-5-amine is used as a chemical intermediate for the synthesis of drugs with potential anti-cancer, anti-inflammatory, or anti-microbial properties. The presence of methylsulfanyl groups enhances its importance in developing new drugs.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4,6-bis(methylsulfanyl)pyrimidin-5-amine serves as a valuable tool for researchers. Its unique chemical structure allows for the exploration of new drug candidates and the advancement of drug discovery efforts.
Used in Organic Synthesis:
4,6-bis(methylsulfanyl)pyrimidin-5-amine is utilized in organic synthesis to create a variety of complex organic compounds. Its versatile structure makes it a useful component in the development of novel chemical entities.

Upstream product

• 5413-85-4 5-amino-4,6-dichloropyridimine 
• 5188-07-8 sodium thiomethoxide 
• 88317-72-0 4,6-bismethylthio-5-nitropyrimidine 

Downstream Products

• 866410-45-9 2-(3-methoxyphenyl)-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine 
• 866410-46-0 7-(methylthio)-2-(3-nitrophenyl)[1,3]thiazolo[5,4-d]pyrimidine 
• 866410-49-3 2-[3-(chloromethyl)phenyl]-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine 
• 866410-61-9 2-[4-(chloromethyl)phenyl]-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine 
• 866410-47-1 2-(3-methoxybenzyl)-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine 
• 96834-28-5 N-(3'-chloro-2',6'-dinitro-4'-trifluoromethylphenyl)-5-amino-4,6-dimethylthiopyrimidine 

Relevant academic research and scientific papers

THIAZOLOPYRIMIDINE DERIVATIVE

The present invention provides a compound represented by the following Formula: wherein A is an aryl group or a heteroaryl group, each of which may be substituted; R 1 is a group which is bonded through carbon; R 2 is hydrogen or an aliphatic hydrocarbon group; and X is -NR 3 -, -O-, -S-, -SO-, -SO 2 -, or -CHR 3 -(wherein R 3 is hydrogen or an aliphatic hydrocarbon group), or a salt thereof, or a prodrug thereof, which has growth factor receptor tyrosine kinase inhibitory activity and low toxicity, and is useful for prevention and treatment of cancer, and thus can be sufficiently used as a medicine.

The Synthesis and Chemistry of 2-Methylpyrimidine-4,6-dithiol and Some Related Compounds

2-Methylpyrimidine-4,6-ditiol has been synthesized and has been converted into 2-methyl-6-methylthiopyrimidine-4-thiol, 4,6-bismethylthiopyrimidine and 6,6'-dithiobis(2-methylpyrimidine-4-thiol).Oxidation of 4,6-bismethylthio-2-methylpyrimidine with 1, 2, 3 and 4 equiv. of m-chloroperbenzoic acid has been shown to result in the formation of the easily isolable methylsulfinyl(methylthio)-, bis(dimethylsulfinyl)-, methylsulfinyl(methylsulfonyl)- and bismethylsulfonyl-pyrimidine, respectively.Some further reactions of the above compounds are described and the synthesis of some other pyrimidines having sulfur-containing substituents is also described.