63115-95-7

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 353-85-5 trifluoroacetonitrile 
• 711-38-6 4'-methoxy-2,2,2-trifluoroacetophenone 

Downstream Products

• 1078145-50-2 ethyl 2,2,2-trifluoro-1-(4-methoxyphenyl)ethylidenecarbamate 
• 1030852-40-4 (-)-(4S)-4-amino-4-(4-methoxyphenyl)-5,5,5-trifluoropentan-2-one 
• 1212262-35-5 C₁₂H₁₄F₃NO₂ 

Relevant academic research and scientific papers

Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin

Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-unprotected ketimines is realized for the first time by employing chiral BIBOP-type ligands with a Rh loading as low as 1 mol %. A range of chiral α-trifluoromethyl-α,α-diaryl α-tertiary amines or 3-amino-3-aryloxindoles were formed with excellent ee values and yields by employing either WingPhos or PFBO-BIBOP as the ligand. The method has enabled an efficient enantioselective synthesis of cipargamin.

Enantioselective Friedel–Crafts Alkylation Reaction of Heteroarenes with N-Unprotected Trifluoromethyl Ketimines by Means of Chiral Phosphoric Acid

An enantioselective Friedel–Crafts alkylation reaction of pyrroles and indoles with N-unprotected trifluoromethyl ketimines by use of chiral phosphoric acid provided α-trifluoromethylated primary amines bearing chiral tetrasubstituted carbon centers in high yields and with high to excellent enantioselectivities. The present reaction is unique to N-unprotected trifluoromethyl ketimines. No reaction took place with N-p-methoxyphenyl (PMP)-substituted ketimine. Corresponding α-trifluoromethylated amines were transformed without loss of enantioselectivity.

Tertiary amine compound, bisphosphine ligand, and intermediate and preparation method of tertiary amine compound

The invention discloses a tertiary amine compound, a bisphosphine ligand, and an intermediate and a preparation method of the tertiary amine compound, and provides a tertiary amine compound preparation method, which comprises: under the protection of a ga

Direct access to: N -unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N -unprotected trifluoromethyl ketimines

Direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines is reported for the first time. A combination of catalytic amounts of diethylzinc and carboxylic acids promoted the reactions under proton-transfer conditions, allowing an unprecedented direct access to N-unprotected α-tetrasubstituted primary amines without additional deprotection steps.