63125-40-6

Usage

Uses

Used in Pharmaceutical Industry:
1-Oxo-1,2-dihydroisoquinoline-4-carbaldehyde is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential therapeutic applications. Its unique biological activity, including antifungal, antibacterial, and antimalarial properties, makes it a valuable component in the development of new drugs.
Used in Organic Chemistry:
1-Oxo-1,2-dihydroisoquinoline-4-carbaldehyde is used as a building block in organic synthesis for the creation of more complex molecules. Its presence of a formyl (-CHO) group and the "1-oxo" oxygen-containing group allows for further chemical reactions and modifications, making it a versatile compound in organic chemistry research and development.

InChI:InChI=1/C10H7NO2/c12-6-7-5-11-10(13)9-4-2-1-3-8(7)9/h1-6H,(H,11,13)

Upstream product

• 1005772-69-9 1-methoxy-4-isoquinolinecarboxaldehyde 
• 3951-95-9 4-bromo-1,2-dihydroisoquinolin-1-one 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

Gold/Lewis acid catalyzed oxidative cyclization involving activation of nitriles

A gold-catalyzed oxidative cyclization of alkyne-nitriles using water or alcohol as the external nucleophiles has been developed. The catalytic system, featured with gold and Lewis acid dual catalysis, allows a facile synthesis of functionalized isoquinolin-1(2H)-ones and 1-alkoxy-isoquinolines with a wide structural diversity. This journal is

Simple synthesis of 4-substituted 1(2H)-isoquinolinones via electrophilic trapping of lithiated mono- and dianion precursors

Synthetic routes have been developed to access 4-substituted 1(2H)-isoquinolinones from readily available precursors. This is achieved via electrophilic trapping of di- and monolithium anions derived from alkyllithium exchange of 4-bromo-1(2H)-isoquinolinones and corresponding 4-bromo-1- methoxyisoquinolines, respectively. Products derived from the latter are then hydrolyzed to the target 4-substituted 1(2H)-isoquinolinones. The methodology has potential application to access 4-substituted 1(2H)-isoquinolinones with additional substituents in either ring. Copyright Taylor & Francis Group, LLC.