6313-55-9

Basic information

• Product Name: 2-amino-6-chloropyridine-4-carboxylic acid
• Synonyms: 2-amino-6-chloropyridine-4-carboxylic acid;6-AMINO-2-CHLORO-NICOTINIC ACID;2-aMino-6-chloroisonicotinic acid;2-Amino-6-chloropyridine-4-carboxylic acid, 2-Amino-4-carboxy-6-chloropyridine;2-Amino-6-chloroisonicotinic acid
• CAS NO: 6313-55-9
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.57
• Mol File: 6313-55-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 295-304°C
• Boiling Point: 520.7°C at 760 mmHg
• Flash Point: 268.7°C
• Appearance: /
• Density: 1.577g/cm³
• Vapor Pressure: 1.14E-11mmHg at 25°C
• Refractive Index: 1.66
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: 2-amino-6-chloropyridine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-chloropyridine-4-carboxylic acid(6313-55-9)
• EPA Substance Registry System: 2-amino-6-chloropyridine-4-carboxylic acid(6313-55-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6313-55-9(Hazardous Substances Data)

Usage

General Description

2-amino-6-chloropyridine-4-carboxylic acid is a chemical compound with the molecular formula C6H5ClN2O2. It is a heterocyclic compound containing a pyridine ring with a chloro substituent at the 6 position and a carboxylic acid group at the 4 position. 2-amino-6-chloropyridine-4-carboxylic acid is commonly used in chemical and pharmaceutical synthesis, particularly in the production of pharmaceutical drugs and organic compounds. It has potential applications in the development of new drugs and biologically active molecules due to its structural properties and reactivity. Additionally, 2-amino-6-chloropyridine-4-carboxylic acid can also be used as a building block in the synthesis of novel materials and organic compounds for various industrial applications.

InChI:InChI=1/C6H5ClN2O2/c7-4-1-3(6(10)11)2-5(8)9-4/h1-2H,(H2,8,9)(H,10,11)

Upstream product

• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 

Downstream Products

• 1005508-80-4 methyl 2-amino-6-chloropyridine-4-carboxylate 
• 1365839-25-3 1,1-dimethylethyl 4-{[4-(hydroxymethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyridinyl]amino}-1-piperidinecarboxylate 
• 1365839-28-6 1,1-dimethylethyl (3S)-3-{[4-(hydroxymethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyridinyl]amino}-1-pyrrolidinecarboxylate 
• 28056-05-5 ethyl 2-amino-6-chloroisonicotinate 
• 51501-52-1 3,4,5,6-tetrachloro-pyridin-2-ylamine 
• 1334294-36-8 (2-amino-6-chloropyridin-4-yl)methanol 

Relevant articles and documents

SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of Formula (A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R5 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Itk activity.