63134-12-3

Usage

InChI:InChI=1/C22H39ClN2O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-28(26,27)25-20-16-17-21(23)22(24)19-20/h16-17,19,25H,2-15,18,24H2,1H3

Upstream product

• 288-32-4 1H-imidazole 
• 38775-38-1 1-hexadecanesulfonyl chloride 
• 5131-60-2 4-chloro-1,3-phenylenediamine 

Relevant academic research and scientific papers

Process for preparing N-(3-amino-4-chlorophenyl) acylamides

The present invention provides a process for preparing N-(3-amino-4-chlorophenyl) acylamides of Formula I: STR1 comprising reacting, in a solvent comprising at least one polar solvent, in the presence of at least one acid acceptor, 1-chloro-2,4-diaminobenzene with at least one acyl chloride of formula I: wherein X is --CO-- or --SO2 --; R is selected from the group C1 -C25 alkyl; C1 -C25 alkyl substituted with one or more groups selected from C1 -C12 alkoxy, aryl, aryloxy and C5 -C7 cycloalkyl; aryl; C5 -C7 cycloalkyl. The present invention further comprises the step of purifying said N-(3-amino-4-chlorophenyl) acylamides by crystallizing from a non-polar solvent or conducting the reaction in a mixture of at least one polar and at least one non-polar solvent.