63136-23-2

Basic information

• Product Name: 8-Ethyl-4-hydroxy-2-methylquinoline
• Synonyms: 8-Ethyl-2-methyl-4(1H)-quinolinone([62510-41-1]);8-Ethyl-2-methylquinolin-4-ol, 8-Ethyl-4-hydroxyquinaldine
• CAS NO: 63136-23-2
• Molecular Formula: C12H13NO
• Molecular Weight: 187.24
• Mol File: 63136-23-2.mol

Chemical Properties

• Boiling Point: 310°C at 760 mmHg
• Flash Point: 127.2°C
• Appearance: /
• Density: 1.083g/cm³
• Vapor Pressure: 0.000616mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 8-Ethyl-4-hydroxy-2-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Ethyl-4-hydroxy-2-methylquinoline(63136-23-2)
• EPA Substance Registry System: 8-Ethyl-4-hydroxy-2-methylquinoline(63136-23-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 63136-23-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
8-Ethyl-4-hydroxy-2-methylquinoline is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a key component in the development of new drugs and pesticides.
Used in Metalworking Industry:
8-Ethyl-4-hydroxy-2-methylquinoline is used as a corrosion inhibitor in metalworking. Its ability to protect metal surfaces from corrosion makes it a valuable asset in this industry.
Used in Textile Industry:
8-Ethyl-4-hydroxy-2-methylquinoline is used as a dye intermediate in the textile industry. Its chemical properties enable it to be a part of the process in creating various dyes for fabrics.
Used in Antimicrobial Applications:
8-Ethyl-4-hydroxy-2-methylquinoline is used as an antimicrobial agent due to its ability to inhibit the growth of microorganisms. This makes it a potential candidate for use in various applications where microbial control is necessary.
Used in Antioxidant Applications:
8-Ethyl-4-hydroxy-2-methylquinoline is used as an antioxidant, which helps prevent the oxidation of other molecules. Its antioxidant properties make it useful in various industries where oxidation can lead to degradation or spoilage.

InChI:InChI=1/C12H13NO/c1-3-9-5-4-6-10-11(14)7-8(2)13-12(9)10/h4-7H,3H2,1-2H3,(H,13,14)

Upstream product

• 63136-21-0 C₁₄H₁₉NO₂ 
• 578-54-1 ortho-ethylaniline 

Downstream Products

• 63136-24-3 4-Cl-8-Aethyl-chinaldin 

Relevant articles and documents

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.