6314-23-4

Basic information

• Product Name: 1-(2-HYDROXYETHYL)-PYRAZOLE
• Synonyms: N-(B-HYDROXYETHYL)PYRAZOLE;AKOS B021981;AKOS PAO-0963;1-(2-HYDROXYETHYL)-PYRAZOLE;ART-CHEM-BB B021981;1-(2-Hydroxyethyl)-1H-pyrazole;2-(1H-Pyrazol-1-yl)ethan-1-ol;2-(1H-Pyrazol-1-yl)ethanol
• CAS NO: 6314-23-4
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.13
• Product Categories: Azoles;blocks
• Mol File: 6314-23-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 236.6 °C at 760 mmHg
• Flash Point: 96.9 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 0.0258mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C
• PKA: 14.39±0.10(Predicted)
• CAS DataBase Reference: 1-(2-HYDROXYETHYL)-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-HYDROXYETHYL)-PYRAZOLE(6314-23-4)
• EPA Substance Registry System: 1-(2-HYDROXYETHYL)-PYRAZOLE(6314-23-4)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6314-23-4(Hazardous Substances Data)

Usage

General Description

1-(2-Hydroxyethyl)-pyrazole is a chemical compound with the molecular formula C5H8N2O. It is a derivative of pyrazole, a heterocyclic organic compound. This chemical has a hydroxyethyl group attached to the pyrazole ring, giving it unique properties and potential applications in various fields. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Additionally, it is also used in research and development as a reagent or catalyst in organic synthesis. Its structure and properties make it an important component in the study and development of new and innovative chemical compounds.

InChI:InChI=1/C5H8N2O/c8-5-4-7-3-1-2-6-7/h1-3,8H,4-5H2

Upstream product

• 288-13-1 NH-pyrazole 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 689152-76-9 1-[2-(4-nitrophenoxy)ethyl]-1H-pyrazole 
• 1562526-48-0 2-(2-(1H-pyrazol-1-yl)ethyl)-6-(benzyloxy)-4-(benzyloxymethyl)-1,2,4-triazine-3,5(2H,4H)-dione 
• 1562526-45-7 2-(2-(1H-pyrazol-1-yl)ethyl)-4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione 
• 96450-53-2 1-(β-chloroethyl)pyrazole 
• 1082065-98-2 1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde 
• 864723-36-4 1-(2-chloroethyl)-4-formylpyrazole 
• 1093207-55-6 2-(2-(1H-pyrazol-1-yl)ethoxy)-6-nitrobenzonitrile 
• 80200-52-8 1-isopropylamino-3-[4-[2-(1-pyrazolyl)ethylthio]phenoxy]-2-propanol 
• 80200-14-2 4-[2-(1-pyrazolyl)ethylthio]phenol 
• 80200-20-0 1-[2-(p-toluenesulfonyloxy)ethyl]pyrazole 

Relevant articles and documents

N-terminal strategy (N1-N4) toward high performance liquid crystal materials

Liquid crystal materials have a variety of applications in many fields such as display techniques as well as photonics and optics. However, only few design principles have been disclosed on liquid crystal materials with different N-heterocycles as the terminal groups, which hinder the development of the heterocyclic liquid crystals. Here, a strategy of molecular design for N-heterocyclic liquid crystal materials is reported. On the basis of this strategy, a series of convenient N-heterocycles such as pyrrole, pyrazole, imidazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,3,4-tetrazole were applied to synthesize the novel liquid crystals. Most of them have proved to exhibit good mesomorphic behaviors which make them excellent components in the mixture of the LCDs materials. The simple attachment of N-heterocyclic units to the liquid crystal molecules through a mild reaction condition will provide a good prospect for the design of N-heterocyclic liquid crystals.

ALKYLATION OF AZOLES USING beta -FUNCTIONAL ALKYL HALIDES UNDER CONDITIONS OF PHASE TRANSFER CATALYSIS.

The objective of this study was to develop a convenient synthetic method for direct N-alkylation of pyrazole (I), 3(5)-methylpyrazole (II), 3,5-dimethylpyrazole (III), 1,2,4-triazole (IV), and tetrazole (V) using beta -functional alkyl halides under conditions of two-phase catalysis and with high product yields. This investigation was stimulated by the fact that the desired reaction products are intermediates in the synthesis of an important class of compounds, vinylazole, as well as of various pharmaceutical agents. It is found that depending on the acidity of the azole, alkylation with dichloroethane can be accompanied by beta -elimination. The effect of solvent on the course of alkylation reactions using dichloroethane has also been studied, and revealed that the reactions occur via the intermediacy of ion pairs rather than free anions.