6314-23-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Hydroxyethyl)-pyrazole is used as a building block for the synthesis of various pharmaceuticals due to its unique chemical structure, which can be modified to create new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2-Hydroxyethyl)-pyrazole is utilized as a component in the development of new agrochemicals, leveraging its chemical properties to enhance crop protection and yield.
Used in Organic Synthesis Research and Development:
1-(2-Hydroxyethyl)-pyrazole is employed as a reagent or catalyst in organic synthesis, facilitating the creation of new organic compounds for a wide range of applications, from materials science to specialty chemicals.
Used in Chemical Compound Development:
As an important component in the study and development of innovative chemical compounds, 1-(2-Hydroxyethyl)-pyrazole contributes to the advancement of chemical science by enabling the exploration of novel chemical reactions and the synthesis of previously unattainable molecules.

InChI:InChI=1/C5H8N2O/c8-5-4-7-3-1-2-6-7/h1-3,8H,4-5H2

Upstream product

• 288-13-1 NH-pyrazole 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 80200-14-2 4-[2-(1-pyrazolyl)ethylthio]phenol 
• 80200-52-8 1-isopropylamino-3-[4-[2-(1-pyrazolyl)ethylthio]phenoxy]-2-propanol 
• 689152-76-9 1-[2-(4-nitrophenoxy)ethyl]-1H-pyrazole 
• 864723-36-4 1-(2-chloroethyl)-4-formylpyrazole 
• 1082065-98-2 1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde 
• 96450-53-2 1-(β-chloroethyl)pyrazole 
• 1562526-45-7 2-(2-(1H-pyrazol-1-yl)ethyl)-4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione 
• 1562526-48-0 2-(2-(1H-pyrazol-1-yl)ethyl)-6-(benzyloxy)-4-(benzyloxymethyl)-1,2,4-triazine-3,5(2H,4H)-dione 
• 1093207-55-6 2-(2-(1H-pyrazol-1-yl)ethoxy)-6-nitrobenzonitrile 
• 80200-20-0 1-[2-(p-toluenesulfonyloxy)ethyl]pyrazole 

Relevant academic research and scientific papers

N-terminal strategy (N1-N4) toward high performance liquid crystal materials

Liquid crystal materials have a variety of applications in many fields such as display techniques as well as photonics and optics. However, only few design principles have been disclosed on liquid crystal materials with different N-heterocycles as the terminal groups, which hinder the development of the heterocyclic liquid crystals. Here, a strategy of molecular design for N-heterocyclic liquid crystal materials is reported. On the basis of this strategy, a series of convenient N-heterocycles such as pyrrole, pyrazole, imidazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,3,4-tetrazole were applied to synthesize the novel liquid crystals. Most of them have proved to exhibit good mesomorphic behaviors which make them excellent components in the mixture of the LCDs materials. The simple attachment of N-heterocyclic units to the liquid crystal molecules through a mild reaction condition will provide a good prospect for the design of N-heterocyclic liquid crystals.

Alkylation of pyrazoles with ethylene chlorohydrin under phase transfer catalysis

Alkylation reactions of pyrazoles with ethylene chlorohydrin under phase transfer catalysis were studied. Effect of solvent nature on alkylation process was established. 3(5)-Methylpyrazole alkylation products were isolated and identified.

ALKYLATION OF AZOLES USING beta -FUNCTIONAL ALKYL HALIDES UNDER CONDITIONS OF PHASE TRANSFER CATALYSIS.

The objective of this study was to develop a convenient synthetic method for direct N-alkylation of pyrazole (I), 3(5)-methylpyrazole (II), 3,5-dimethylpyrazole (III), 1,2,4-triazole (IV), and tetrazole (V) using beta -functional alkyl halides under conditions of two-phase catalysis and with high product yields. This investigation was stimulated by the fact that the desired reaction products are intermediates in the synthesis of an important class of compounds, vinylazole, as well as of various pharmaceutical agents. It is found that depending on the acidity of the azole, alkylation with dichloroethane can be accompanied by beta -elimination. The effect of solvent on the course of alkylation reactions using dichloroethane has also been studied, and revealed that the reactions occur via the intermediacy of ion pairs rather than free anions.