6314-41-6

Usage

Chemical structure

A benzothiophene ring attached to a 4-chlorophenyl group and a methanol molecule.

Industry use

Commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drugs.

Biological and pharmacological activities

Studied for potential as an antifungal agent and as a potential anticancer drug.

Organic chemistry

Investigated for potential use in organic chemistry reactions and as a building block for the synthesis of complex organic compounds.

Versatility

Wide range of potential applications in various fields.

Upstream product

• 50779-55-0 benzothiophen-2-yllithium 
• 104-88-1 4-chlorobenzaldehyde 
• 95-15-8 Benzo[b]thiophene 

Downstream Products

• 121801-77-2 2-[Chloro-(4-chloro-phenyl)-methyl]-benzo[b]thiophene 
• 163083-16-7 benzo[b]thiophene-2-yl(4-chlorophenyl)methanone 
• 3139-49-9 2-(4-chlorobenzyl)benzo[b]thiophene 
• 121801-90-9 1-[Benzo[b]thiophen-2-yl-(4-chloro-phenyl)-methyl]-1H-imidazole 
• 219506-00-0 (4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[b]thiophen-2-yl]-methanone 
• 163083-14-5 2-(4-chlorobenzoyl)benzo[b]thiophene 1-oxide 

Relevant academic research and scientific papers

Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, bicyclic or tricyclic carbon or heterocyclic ring biphenylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin

Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

Synthesis of (4-chlorophenyl)-(1-oxo-1λ4-benzo[b]thien-2-yl)methanone and study of its reactivity towards sulfur- and oxygen-containing nucleophiles

(4-Chlorophenyl)-(1-oxo-1λ4-benzo[b]thien-2-yl)methanone 2a was synthesized by oxidation of the corresponding benzo[b]thiophene derivative 2 with the oxidative system H2O2/TFA. This benzo[b]thiophene sulfoxide undergoes Michael-type nucleophilic addition of sulfur- and oxygen-containing nucleophiles either under basic conditions leading to 2,3-dihydro-3- substituted-benzo[b]-thiophene 1-oxides or in acidic media leading then to rearomatized 3-substituted-benzo[b]thiophenes. This method provides an easy two-step functionalization of 2-acyl-benzo[b]thiophene derivatives.

THIENYL-, FURYL- AND PYRROLYL SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN

Thienyl-, furyl-and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl) furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

New imidazole anti-fungal agents derived from benzothiophene. Part II

1-thienyl)methyl>-1H-imidazoles 22, 1-thien-3-yl)(thienyl)methyl>-1H-imidazoles 25 and 1-thien-3-yl)methyl>-1H-imidazoles 28 have been synthesized and tested for anti-fungal activity.All compounds showed good activity against a broad spectrum of fungi (yeasts, dermatophytes).