6314-62-1

Usage

General Description

2-(benzylamino)-1-(4-chlorophenyl)ethanol, also known as Phenibut, is a central nervous system depressant and derivative of the neurotransmitter gamma-aminobutyric acid (GABA). It is commonly used as a recreational drug for its anxiolytic and sedative effects, and has also been marketed as a dietary supplement for its potential nootropic and mood-enhancing properties. Phenibut is believed to work by binding to GABA receptors in the brain, leading to an increase in GABA levels and a reduction in neuronal excitability. However, it can also be addictive and has the potential for withdrawal symptoms and side effects, making it important to use caution and consult with a healthcare professional before using 2-(benzylamino)-1-(4-chlorophenyl)ethanol.

Upstream product

• 2788-86-5 4-Chlorostyrene oxide 
• 100-46-9 benzylamine 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 182621-75-6 (R)?2?bromo?1?(4′?chlorophenyl)ethanol 
• 2788-86-5 (R)-2-(4-chlorophenyl)oxirane 

Relevant academic research and scientific papers

Nickel-Catalyzed Regio- And Stereospecific C-H Coupling of Benzamides with Aziridines

A nickel-catalyzed C-H coupling of 8-aminoquinoline-derived benzamides with aryl- and alkyl-substituted aziridines has been disclosed. The current strategy provides direct access to benzolactams by the C-H alkylation-intramolecular amidation cascade event with the concomitant removal of the aminoquinoline auxiliary. The regioselectivity of ring opening of aziridines can be controlled by the substituents. The reaction with chiral aziridines proceeds with inversion of configuration, thus suggesting an SN2-type nucleophilic ring-opening pathway.

Asymmetric synthesis of 2-arylpiperazines

An asymmetric synthesis of 2-arylpiperazines starting from phenacyl bromides, a variety of which are easily available, has been established. The synthesis features a CBS reduction of phenacyl bromide to provide optically enriched compounds, an SN2 reaction of 1,2,3-oxathiazolidine 2-oxides with an azide anion with invert of configuration, and construction of the piperazine ring via reduction of piperazine-2,3-diones.

2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES

A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.