63141-08-2Relevant academic research and scientific papers
Synthetic method of 1-halo-1-acetyl cyclopropane
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Paragraph 0020; 0021, (2018/03/24)
The invention discloses a synthetic method of 1-halo-1-acetyl cyclopropane. The synthetic method comprises the step of preparing a 1-halo-1-acetyl cyclopropane compound by taking 3,5-dihalo-pentanoneas a raw material and taking benzyl trimethyl ammonium chloride as a phase transfer catalyst under the action of alkali. The method disclosed by the invention is simple to operate, quick to react andhigh in yield, and solves the problem of quickly and efficiently synthesizing the 1-halo-1-acetyl cyclopropane compound. The synthetic method disclosed by the invention is primarily used for synthesizing organic molecules containing cyclopropane structural units.
Design and synthesis of novel spirocyclopropyl cyclohexane-1,3-diones and -1,3,5-triones for their incorporation into potent HPPD inhibitors
Beaudegnies, Renaud,De Mesmaeker, Alain,Mallinger, Aurélie,Baalouch, Myriam,Goetz, André
scheme or table, p. 2741 - 2744 (2010/06/14)
We report the design and the efficient synthesis of novel spirocyclopropyl cyclohexane-1,3-dione and -1,3,5-trione units to be incorporated into potent HPPD inhibitors. New routes involving original combinations of synthetic equivalents of α-cyclopropyl ketone-α-anion and α-cyclopropyl ester-β-cation are described.
SYNTHESIS OF SUBSTITUTED METHYLENECYCLOPROPANES BY METALLATION OF CYCLOPROPYL BROMIDES CONTAINING A METHYLENECYCLOPROPANE FRAGMENT
Donskaya, N. A.,Akhachinskaya, T. V.,Leonova, T. V.,Shulishov, E. V.,Shabarov, Yu. S.
, p. 487 - 493 (2007/10/02)
In the reaction of 1-cyclopropyl-1-(1-bromocyclopropyl)methylenecyclopropane and 1-methyl-1-(1-bromocyclopropyl)methylenecyclopropane with butyllithium or magnesium in tetrahydrofuran the organometallic derivatives of cyclopropyl-substituted methylenecyclopropanes with the metal atom in the cyclopropane fragment are formed.The reaction of the obtained organometallic compounds with electrophilic agents can be used to introduce deuterium, the trimethylsilyl group, and other substituents into the cyclopropane fragment.The metallation of the above-mentioned bromides with methyllithium is not suitable for the synthesis of organometallic compo unds, since the alkylation products are formed quantitatively.When treated with magnesium in tetrahydrofuran with subsequent decomposition with water, 1,1-di(1-bromocyclopropyl)-methylenecyclopropane gives a mixture of 4-cyclopropylidenedispiroheptane and 1,1-dicyclopropylmethylenecyclopropane, the composition of which depends on the reaction conditions.
