63144-62-7

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 63144-61-6 1-methoxy-3-(3-(4-methoxyphenyl)propyl)benzene 
• 52182-14-6 (2E)-3-(3-methoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 591-31-1 3-methoxy-benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant academic research and scientific papers

Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols

We describe an aerobic intramolecular dearomative coupling reaction of tethered phenols using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products

A mild and efficient method for the vanadium-catalyzed intramolecular coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor.