63153-19-5

Upstream product

• 4460-86-0 asaraldehyde 
• 14382-91-3 2-hydroxy-4,5-dimethoxybenzaldehyde 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 909415-80-1 2-{[1-(4,5-Dimethoxy-2-methoxymethoxy-phenyl)-meth-(E)-ylidene]-amino}-3-methyl-phenol 
• 1459201-79-6 (2-hydroxy-4,5-dimethoxybenzyl)triphenylphosphonium bromide 
• 1459201-82-1 5,6-dimethoxy-2-(2-(2,6,6-trimethylcyclohex-1-enyl)ethyl)benzofuran 
• 1311270-91-3 tert-butyl(4,5-dimethoxy-2-(methoxymethoxy)benzyloxy)dimethylsilane 
• 1311270-90-2 4,5-dimethoxy-2-(methoxymethoxy)benzyl acetate 
• 909415-77-6 2-(4,5-dimethoxy-2-methoxymethoxyphenyl)-4-(2-pyridylmethyl)aminomethyl-benzoxazole 
• 909415-75-4 4-bromomethyl-2-(4,5-dimethoxy-2-methoxymethoxyphenyl)benzoxazole 
• 657358-45-7 2-(4,5-dimethoxy-2-methoxymethoxyphenyl)-4-methylbenzoxazole 

Relevant academic research and scientific papers

BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF P13K- a AND/OR B

Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.

BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF PI3K-alpha AND/OR beta

Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described [formula 1] together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention. The claimed Markush formula is: [Formular 1], Y can be O, NH, NR, S; Representative compounds are: [Compounds A, B, C, D]

Pt(IV)-catalyzed generation and [4+2]-cycloaddition reactions of o-quinone methides

Novel intermolecular and intramolecular generations of ortho-quinone methides and their formal [4+2]-cycloaddition reactions with olefins catalyzed by PtCl4 and AuCl3 under mild conditions have been developed. Good to excellent yields (up to 99%) and diastereoselectivity (up to >99:1) of the chromans were obtained. PtCl4 was found to be effective and compatible with various functional groups present in the substrates. A mechanism accounting for its catalytic cycle is proposed and discussed.

Zinc-chelating ratiometric fluorescent probes and related methods

Benzoxazole fluorescent sensor compounds and related ratiometric imaging methods for zinc metal ion.

Emission Ratiometric Imaging of Intracellular Zinc: Design of a Benzoxazole Fluorescent Sensor and Its Application in Two-Photon Microscopy

Zinc and calcium are ubiquitous intracellular metals, and while a variety of quantitative probes have been developed for measuring intracellular changes in calcium concentration, the same is not true of zinc. We describe here the design, synthesis, and pr