63153-37-7Relevant academic research and scientific papers
Synthesis of fused oxazole-containing coumarin derivatives via oxidative cross coupling reaction using a combination of CuCl2 and TBHP
Belal, Md.,Khan, Abu T.
, p. 18891 - 18894 (2016)
Various fused oxazoles containing coumarin derivatives were synthesized via an oxidative cross coupling reaction by employing 20 mol% CuCl2 as the catalyst and TBHP as an oxidant. The reaction proceeds through functionalization of a C-H bond by
Synthesis and reactions of 3-aroyl derivatives of 4-hydroxy-2-quinolones and 4-hydroxycoumarin
Kappe, Thomas,Schnell, Barbara
, p. 663 - 670 (2007/10/03)
3-Aroyl-4-hydroxy-2-quinolones 4 and 11 can be synthesized starting with 1 or 9 via Fries rearrangement of the corresponding esters 3 and 10, catalyzed by potassium cyanide and 18-crown-6. A one pot procedure is presented in which the esters do not need to be isolated. Reduction of the aryl ketones 4 and 11 with zinc dust leads to the benzyl derivatives 5 and 12. Reaction of the aryl ketones 4 and 11 with hydroxylamine and subsequent heating of the crude product leads via thermal Beckmann rearrangement and dehydration to oxazoloquinolones 7 and 14. 2-Aroyloxypyrido[1,2-a]pyrimidin-4-ones 17 and 20 could not be converted to the corresponding ketones by Fries rearrangement.
