6318-36-1

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 76979-36-7 5-(2-chlorophenylmethylene)-3-methyl-4-oxo-2-thioxothiazolidine 
• 76979-32-3 5-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-2-methylsulfanyl-thiazol-4-one 
• 952576-83-9 Mo(CO)5[5-(2-chlorobenzylidene)rhodanine] 
• 7282-55-5 3-(2-chlorophenyl)-2-sulfanylpropenoic acid 
• 145903-72-6 piperidine salt of (E,Z)-5-(2-chlorophenylmethylene)-4-oxo-2-thioxothiazolidine 
• 36937-41-4 5-(2-chlorophenylmethylene)-2-piperidino-4-oxo-2-thiazoline 
• 65562-28-9 5-(2-chloro-benzylidene)-3-(tetra-O-acetyl-β-D-glucopyranosyl)-2-thioxo-thiazolidin-4-one 
• 36946-73-3 5-(2-Chlorophenylmethylene)-2-imino-4-thiazolidinone 
• 76979-46-9 5-(2-Chlorophenylmethylene)-2-(4-methoxyphenylmethylimino)-4-thiazolidinone 
• 76979-44-7 5-(2-chlorophenylmethylene)-2-(4-methylphenylmethylimino)-4-oxothiazolidine 
• 76979-42-5 5-(2-Chlorophenylmethylene)-2-(phenylmethylimino)-4-thiazolidinone 
• 98949-12-3 (Z)-5-(2-chlorobenzylidene)-thiazolidin-2,4-dione 
• 36937-48-1 5-(2-chlorophenylmethylene)-2-morpholino-4-oxo-2-thiazoline 

Relevant academic research and scientific papers

Combination of 4-anilinoquinazoline and rhodanine as novel epidermal growth factor receptor tyrosine kinase inhibitors

Abstract A type of novel rhodanine-based 4-anilinoquinazoline, which designed the combination between quinazoline as the backbone and various substituted biological rhodanine groups as the side chain, have been synthesized, and their antiproliferative act

Facile and convenient synthesis of 5-arylalkylidenerhodanines by electrocatalytic crossed aldol condensation

An electrochemically induced catalytic crossed Aldol condensation of one equivalent of rhodanine with various aromatic aldehydes and ketones in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of th

Urea/thiourea catalyzed, solvent-free synthesis of 5-arylidenethiazolidine- 2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones

An efficient and organo-catalyzed method has been developed for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2- thioxothiazolidin-4-ones via Knoevenagel condensation of arylaldehydes 1 and 2,4-thiazolidinedione 2a/2-thioxothiazolidin-4-one 2b under mild conditions. Urea-adduct 4 and azomethine 5 also afford arylidene-products 3 by reacting with 2a-b via addition-elimination reaction. This protocol has the features of use of inexpensive, ecofriendly readily available, effective catalyst system viz. urea/thiourea, avoidance of volatile solvents, excellent yield and simple work-up procedure.

A solvent-free protocol for the green synthesis of arylalkylidene rhodanines in a task-specific ionic liquid

2-Hydroxyethylammonium formate acts as a task-specific ionic liquid (TSIL) for the Knoevenagel condensation of carbonyl compounds with rhodanine to afford arylalkylidene rhodanines under solvent-free conditions and in good-to-excellent yields. Additionally, compared with those in organic solvents, the yields obtained in the presence of our ionic liquid (IL) were significantly increased. The detailed mechanism of the catalytic effect of TSIL is also reported for the first time.

Iodine catalysed synthesis of 5-(arylmethylidene)rhodanines by grinding under solvent-free conditions

5-(Arylmethylidene)rhodanines have been synthesised in 88-95% yields by Knoevenagel condensation of various aromatic aldehydes with rhodanine in the presence of a catalytic amount of iodine at room temperature by grinding under solvent-free conditions.

Green synthesis of 5-benzylidene rhodanine derivatives catalyzed by 1-butyl-3-methyl imidazolium hydroxide in water

A basic functionalized ionic liquid, 1-butyl-3-methyl imidazolium hydroxide ([bmim][OH]), catalyzed the Knoevenagel condensation of rhodanine with aromatic aldehydes. It proceeded smoothly in water to afford the 5-benzylidene rhodamine derivatives in high yields at room temperature. This new method offers several advantages, such as excellent yields, short reaction times, and simple procedure. The catalyst can be reused at least 5 times without significant loss of activity.

Facile synthesis of 5-benzylidene rhodamine derivatives under microwave irradiation

A series of 5-benzylidenerhodamine derivatives were synthesized by the cross-aldol condensation of an aromatic aldehyde with rhodamine or rhodamine acetic acid in sodium acetate/acetic acid under microwave irradiation. The reaction was completed in 8-20 min with 63-94% yields and was environmentally benign with easy workup. Copyright Taylor & Francis Group, LLC.

New structural features in triphenylphosphinesilver(I) sulfanylcarboxylates

We investigated the reactions of 1.5 : 1 : 1 mole ratio mixtures of triphenylphosphine, silver nitrate and 3-(aryl)-2-sulfanylpropenoic acids H 2xspa in chloroform/water, where in the acid nomenclature, spa = 2-sulfanylpropenoato and x = p, Clp