6318-41-8Relevant academic research and scientific papers
Synthesis, biological evaluation and molecular modeling studies of some novel thiazolidinediones with triazole ring
Chinthala, Yakaiah,Kumar Domatti, Anand,Sarfaraz, Alam,Singh, Shailendra Pratap,Kumar Arigari, Niranjan,Gupta, Namita,Satya, Srinivas K.V.N.,Kotesh Kumar, Jonnala,Khan, Feroz,Tiwari, Ashok K.,Paramjit, Grover
, p. 308 - 314 (2013)
A new series of thiazolidinedione derivatives were synthesized and evaluated for in vitro α-glucosidase inhibition and anticancer activities. Compounds 3d, 3e and 3j showed potential α-glucosidase inhibition with IC50 values ranging between 0.1 and 0.3 μg/ml whereas compounds 3i, 3j and 3k have showed better anticancer activity towards human cancer cell lines IMR-32 (neuroblastoma), Hep-G2 (hepatoma) and MCF-7 (breast). Molecular docking studies revealed compounds 3d, 3e and 3j are potent inhibitors of α-glucosidase and also showed compliance with standard parameters of drug likeness.
Synthesis, Antimicrobial Activity and Structure-Activity Relationship of Some 5-Arylidene-thiazolidine-2,4-dione Derivatives
De Paiva, Raíssa K.C.,Da Silva, Jamerson F.,Moreira, Hudieyllen A.,Pinto, Osvaldo G.,Camargo, Lilian T.F.M.,Naves, Plínio L.F.,Camargo, Ademir J.,Ribeiro, Luciano,Ramos, Luciana M.
, p. 164 - 172 (2018/12/13)
Derivatives of the thiazolidine-2,4-dione core represent a heterocyclic class with several correlated properties. In this context, the synthesis of structural analogues of these bioactive substances becomes attractive in the field of medicinal chemistry. These analogues act as antimicrobial agents against Gram-positives pathogens. The present work aimed to synthesize 10 different derivatives of 5-arylidene-thiazolidine-2,4-dione, employing urea as the catalyst in a solvent-free reaction medium, with yields that ranged from 45 to 99percent. The compounds obtained were submitted to an antimicrobial assay against S. aureus ATCC 29213. Two compounds presented minimum inhibitory concentration of 62.5 and 32.5 μg mL-1 and minimum bactericidal concentration -1, demonstrating their antibacterial potential. Principal component analysis was carried out to discriminate the compounds in active and inactive classes. Four geometric and electronic molecular descriptors were required to completely discriminate the compounds. The selected descriptors can guide us in designing new 5-arylidene-thiazolidine-2,4-dione derivatives with enhanced activity.
Synthesis and structure of new 5-(arylidene)-3-(4-methylbenzoyl) thiazolidine-2,4-diones
Popov-Pergal, Katarina M.,Poleti, Dejan,Rancic, Milica P.,Meden, Antun,Pergal, Marija V.
scheme or table, p. 224 - 228 (2010/04/27)
(Chemical Equation Presented) The derivatives of 5-substituted-2,4- thiazolidinedione have a broad spectrum of biological activities. In this article, new 5-(arylidene)-3-(4-methylbenzoyl)thiayolidine-2,4-diones 3a-k, with arylidene groups such as 4-pheny
