631861-02-4

Basic information

• Product Name: C₂₁H₁₇NO₂
• Synonyms: C₂₁H₁₇NO₂
• CAS NO: 631861-02-4
• Molecular Weight: 315.371
• Mol File: 631861-02-4.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₇NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₇NO₂(631861-02-4)
• EPA Substance Registry System: C₂₁H₁₇NO₂(631861-02-4)

Safety Data

• Hazardous Substances Data: 631861-02-4(Hazardous Substances Data)

Upstream product

• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 1711-06-4 3-Methylbenzoyl chloride 

Downstream Products

• 1343483-66-8 C₂₂H₁₉NO₃ 
• 1349134-34-4 N-(2-benzoylphenyl)-4,4-dimethylbiphenyl-2-carboxamide 
• 1349134-33-3 N-(2-benzoylphenyl)-4-methylbiphenyl-2-carboxamide 

Relevant articles and documents

Chiral Phosphoric Acid Catalyzed Kinetic Resolution of 2-Amido Benzyl Alcohols: Asymmetric Synthesis of 4H-3,1-Benzoxazines

An efficient method for the asymmetric synthesis of 4H-3,1-benzoxazines was developed by kinetic resolution of 2-amido benzyl alcohols using chiral phosphoric acid catalyzed intramolecular cyclizations. A broad range of benzyl alcohols (both secondary and tertiary alcohols) were kinetically resolved with high selectivities, with an s factor of up to 94. Mechanistic studies were performed to elucidate the mechanism of these reactions, wherein the amide moieties reacted as the electrophiles. Gram-scale reaction and facile transformations of the chiral products demonstrate the potential of this method in asymmetric synthesis of biologically active chiral heterocycles.