631861-84-2

Upstream product

• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 1037455-28-9 3-(3,4,5-trimethoxyphenyl)-2-methyl-5-trichloromethyl-Δ⁴-1,2,4-oxadiazoline 
• 1037455-50-7 C₁₃H₁₅Cl₃N₂O₄ 
• 1055424-84-4 5-benzo[1,3]dioxol-5-yl-2-methyl-3-(3,4,5-trimethoxy-phenyl)-2,3-dihydro-isoxazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

A torquoselective extrusion of isoxazoline N-oxides. Application to the synthesis of aryl vinyl and divinyl ketones for Nazarov cyclization

A mild, convenient reaction sequence for the synthesis of Nazarov cyclization substrates is described. The [3+2] dipolar cycloaddition of a nitrone and an electron-deficient alkyne gives an isolable isoxazoline intermediate, which upon oxidation undergoes stereoselective extrusion of nitrosomethane to give aryl vinyl or divinyl ketones.

Synthesis of 5-trichloromethyl-Δ4-1,2,4-oxadiazolines and their rearrangement into formamidine derivatives

A series of 5-trichloro-Δ4-1,2,4-oxadiazolines have been synthesised by 1,3-dipolar cycloaddition of nitrones to trichloroacetonitrile. These oxadiazolines rearrange into formamidine derivatives, via ring opening and a 1,2-aryl shift from carbo