6319-55-7Relevant academic research and scientific papers
Synthesis and study of modified polyvinyl alcohol containing amino acid moieties as anticancer agent
Samir, Ali H.,Saeed, Ruwaidah S.,Matty, Fadhel S.
, p. 286 - 294 (2018/03/21)
A series of new phthalimides compounds[3-7]a-i were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo[d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo[d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1]a-i under fusion conditions. Compounds [3-7]a-i react with SOCl2 in the presence of benzene to produce compounds [8-12]a-i. Chemical modification of Poly(vinyl alcohol)were obtained by reaction of PVA with compounds [8-12]a-i using the dimethyl formamide to give compounds [13-17]a-i. The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra, 1H, 13C-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the modified polyvinyl alcohol.
Chiral sensors for determining the absolute configurations of α-amino acid derivatives
Chen, Zhongxiang,Fan, Hongjun,Yang, Shiwei,Bian, Guangling,Song, Ling
, p. 6933 - 6939 (2018/10/02)
A simple strategy for configurational assignments of alpha-amino acids has been developed by comparison of the proton NMR chemical shift values of the alpha hydrogens of N-phthaloyl protected alpha-amino acids in the presence of (R)-CSA 1 and (S)-CSA 1, respectively. Highly resolved NMR spectra can be obtained directly on the mixed solution of the chiral solvating agents with N-phthaloyl protected alpha-amino acids in NMR tubes, giving well distinguishable proton signals without interference which dramatically improve the accuracy of assignment and hasten the assigning procedure. The strategy is widely applicable for varied natural and non-natural amino acids.
Synthesis and evaluation of some N-Mannich bases of isoindole-1,3(2H)-dione derivatives as potential antimicrobial, anthelmintic and insecticidal agents
Bamnela, Rita,Shrivastava
, p. 1128 - 1135 (2014/09/30)
A series of some novel N-Mannich bases of benzimidazolyl substituted 1H-isoindole-1,3(2H) dione have been synthesized by cyclo-condensation of phthalic anhydride with different amino acids and thereafter, condensed with o-phenylenediamine following the Mannich protocol with different amines and formaldehyde to yield the titled compounds 5a-k. The structures of the newly synthesized compounds have been confirmed by FTIR, 1H NMR, mass spectral studies and elemental analyses. All the synthesized compounds have been evaluated for their in vitro antimicrobial, anthelmintic and insecticidal activities against selected microbes, helminthes and insects, compared to standard drugs streptomycin, nystatin, piperazine hydrochloride and cypermethrin respectively. Synthesized compounds 5d, 5j and 5k have shown promising activity against all selected microbes, helminthes and insects, while 5b is strongly toxic against S. aureus, 5g and 5k against B. subtilis, 5i against K. pneumoniae, 5a against T. viride and C. albicans, and 5h against A. niger. Compounds 5f, 5h, 5j, and 5k exhibited good antifungal activity, while 5b, 5g, 5e and 5i are sufficiently toxic for selected bacterial strains. Compounds 5a, 5b, 5c, 5e and 5f are strongly toxic against selected helminthes, while 5a, 5b, 5f, 5g, 5h and 5i have shown promising insecticidal activity.
Photoinduced electron-transfer chemistry of the bielectrophoric N-phthaloyl derivatives of the amino acids tyrosine: Histidine and tryptophan
Griesbeck, Axel G.,Neudoerfl, Joerg,Kiff, Alan De
experimental part, p. 518 - 524 (2011/06/28)
The photochemistry of phthalimide derivatives of the electron-rich amino acids tyrosine, histidine and tryptophan 8-10 was studied with respect to photoinduced electron-transfer (PET)induced decarboxylation and Norrish II bond cleavage. Whereas exclusive photodecarboxylation of the tyrosine substrate 8 was observed, the histidine compound 9 resulted in a mixture of histamine and preferential Norrish cleavage. The tryptophan derivative 10 is photochemically inert and shows preferential decarboxylation only when induced by intermolecular PET.
Protection of amino group as N-phthalyl derivative using microwave irradiation
Khadilkar, Bhushan M.,Madyar, Virendra R.
, p. 1083 - 1085 (2007/10/03)
The amino groups for various substrates are protected as N-phthalyl derivatives using solvent free neat condition under microwave exposure.
Synthesis of the biaryl moiety of the proteasome inhibitors TMC-95 via a ligandless Pd(OAc)2-catalyzed Suzuki-coupling reaction
Ma, Dawei,Wu, Qingquan
, p. 5279 - 5281 (2007/10/03)
The biaryl moiety of proteasome inhibitors TMC-95 was synthesized via a Pd(OAc)2-catalyzed Suzuki-coupling reaction of 7-iodoisatin and a tyrosine-derived arylboronic acid in the absence of phosphine ligands using potassium fluoride as a base.
An expeditious approach for the synthesis of β-hydroxy aryl α-amino acids present in vancomycin
Rama Rao,Chakraborty,Laxma Reddy,Srinivasa Rao
, p. 5043 - 5046 (2007/10/02)
Stereoselective synthesis of the β-hydroxyaryl amino acids which constitute C and E rings of vancomycin is described making use of benzylic oxidation and asymmetric dihydroxylation as the key steps.
SYNTHESIS OF HOMOCHIRAL HYDROXY-α-AMINO ACID DERIVATIVES
Easton, Christopher J.,Hutton, Craig A.,Tan, Eng Wui,Tiekink, Edward R. T.
, p. 7059 - 7062 (2007/10/02)
Treatment of N-phthaloyl-α-amino acid methyl esters with N-bromosuccinimide, followed by reaction with silver nitrate in aqueous acetone, affords homochiral hydroxy-α-amino acid derivatives, the stereochemistry of which is predetermined by that of the starting amino acids.
