631909-07-4Relevant academic research and scientific papers
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
Travins, Jeremy M.,Ali, Farah,Huang, Hui,Ballentine, Shelley K.,Khalil, Ehab,Hufnagel, Heather R.,Pan, Wenxi,Gushue, Joan,Leonard, Kristi,Bone, Roger F.,Soll, Richard M.,DesJarlais, Renee L.,Crysler, Carl S.,Ninan, Nisha,Kirkpatrick, Jennifer,Cummings, Maxwell D.,Huebert, Norman,Molloy, Christopher J.,Gaul, Michael,Tomczuk, Bruce E.,Subasinghe, Nalin L.
, p. 1603 - 1606 (2008/12/21)
Complement activation has been implicated in disease states such as hereditary angioedema, ischemia-reperfusion injury, acute respiratory distress syndrome, and acute transplant rejection. Even though the complement cascade provides several protein target
NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS
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Page 287-288, (2010/02/05)
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
