63193-70-4

Upstream product

• 4755-50-4 4-(dimethylamino)benzoyl chloride 
• 1147550-11-5 ammonium thiocyanate 
• 592-87-0 lead(II) thiocyanate 

Downstream Products

• 1186137-90-5 C₂₉H₃₂ClN₃O₃S 
• 1448365-70-5 11β-(4-dimethylaminobenzoyloxy)-15β-hydroxykaur-16-en-19-oic acid 
• 1442093-69-7 (R)-4-(dimethylamino)-N-(1-hydroxybutan-2-ylcarbamothioyl)benzamide 
• 859734-86-4 4-dimethylamino-N-[(4-ethoxy-phenyl)-thiocarbamoyl]-benzamide 

Relevant academic research and scientific papers

Efficient synthesis of new (R)-2-amino-1-butanol derived ureas, thioureas and acylthioureas and in vitro evaluation of their antimycobacterial activity

The synthesis of 22 structurally diverse urea, thiourea and acylthiourea derivatives containing the (R)-2-amino-1-butanol motif has been performed. The evaluation of their in vitro activity against Mycobacterium tuberculosis (H 37Rv and strain

Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors

An efficient synthetic methodology to provide indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives is described. These conformationally restricted heterobicyclic scaffolds were evaluated as a novel class of HCV inhibitors. Introduction of an acyl group at the NH2 of the thiourea moiety has been found to enhance inhibitory activity. The chain length and the position of the alkyl group on the indoline aromatic ring markedly influenced anti-HCV activity. The indoline scaffold was more potent than the corresponding indole and tetrahydroquinoline scaffolds and analogue 31 displayed excellent activity (EC50 = 510 nM) against HCV without significant cytotoxicity (CC50 >50 μM).

Intramolecular hydrogen bonding and anion binding of N-benzamido-N′- benzoylthioureas

(Chemical Equation Presented) N-(p-Dimethylamino)benzoyl-N′- phenylthiourea as an N-acylthiourea is known to be unable to bind anions due to a strong intramolecular hydrogen bond (IHB). We show here that by inserting an amido group in the N′-phenyl side the newly designed N-benzamido-N′- benzoylthioureas, despite this IHB too, bind strongly to anions with binding constants on the order of 106-107 mol-1 L. Results suggest that potential anion receptors or organocatalysts could be developed on the basis of this framework with a wide structural diversity.