63195-39-1 Usage
Uses
Used in Pharmaceutical Industry:
2,5,6-TRICHLORO-4-METHYLNICOTINONITRILE is used as an intermediate for the preparation of thienopyridines, which are allosteric potentiators of the M4 muscarinic receptor. These potentiators have potential applications in the treatment of various neurological and psychiatric disorders, such as Alzheimer's disease, schizophrenia, and cognitive impairments.
In the synthesis of thienopyridines, 2,5,6-TRICHLORO-4-METHYLNICOTINONITRILE plays a vital role in the formation of the desired active pharmaceutical ingredients (APIs) that can modulate the M4 muscarinic receptor, leading to the desired therapeutic effects. 2,5,6-TRICHLORO-4-METHYLNICOTINONITRILE's unique structure and reactivity make it a valuable building block in the development of novel drugs targeting the M4 muscarinic receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 63195-39-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,1,9 and 5 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 63195-39:
(7*6)+(6*3)+(5*1)+(4*9)+(3*5)+(2*3)+(1*9)=131
131 % 10 = 1
So 63195-39-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H3Cl3N2/c1-3-4(2-11)6(9)12-7(10)5(3)8/h1H3
63195-39-1Relevant academic research and scientific papers
Synthesis of some halogen- and nitro-substituted nicotinic acids and their fragmentation under electron impact
Dyadyuchenko,Strelkov,Mikhailichenko,Zaplishny
, p. 308 - 314 (2007/10/03)
Features of electrophilic and nucleophilic substitution under chlorination and nitration reactions conditions have been investigated for 6-hydroxy- and 6-methyl-substituted derivatives of 3-cyano-4-methyl-2(1H)-pyridones. The polychloro- and nitro-substituted 3-cyano-4-methylpyridines obtained were used as synthons in the synthesis of some polyhalo- and nitro-substituted nicotinic acids and their amides. The fragmentation pathways of the synthesized compounds under electron impact have been studied.
