6320-30-5

Basic information

• Product Name: 4-hydroxy-3-(morpholin-4-ylmethyl)naphthalene-1,2-dione
• CAS NO: 6320-30-5
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 273.2839
• Mol File: 6320-30-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 453.1°C at 760 mmHg
• Flash Point: 227.8°C
• Density: 1.382g/cm³
• Vapor Pressure: 5.36E-09mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 4-hydroxy-3-(morpholin-4-ylmethyl)naphthalene-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-(morpholin-4-ylmethyl)naphthalene-1,2-dione(6320-30-5)
• EPA Substance Registry System: 4-hydroxy-3-(morpholin-4-ylmethyl)naphthalene-1,2-dione(6320-30-5)

Safety Data

• Hazardous Substances Data: 6320-30-5(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 31914-13-3 3-(dimethylsulfonio)-1,2,4-trioxo-1,2,3,4-tetrahydronaphthalenide 
• 7529-22-8 4-methylmorpholine N-oxide 

Relevant articles and documents

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies

A series of nine RuII arene complexes bearing tridentate naphthoquinone-based N,O,O-ligands was synthesized and characterized. Aqueous stability and their hydrolysis mechanism were investigated via UV/vis photometry, HPLC-MS, and density functional theory calculations. Substituents with a positive inductive effect improved their stability at physiological pH (7.4) intensely, whereas substituents such as halogens accelerated hydrolysis and formation of dimeric pyrazolate and hydroxido bridged dimers. The observed cytotoxic profile is unusual, as complexes exhibited much higher cytotoxicity in SW480 colon cancer cells than in the broadly chemo- (incl. platinum-) sensitive CH1/PA-1 teratocarcinoma cells. This activity pattern as well as reduced or slightly enhanced ROS generation and the lack of DNA interactions indicate a mode of action different from established or previously investigated classes of metallodrugs.