63203-41-8

Upstream product

• 652171-09-0 methyl 1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarboxylate 
• 527-69-5 2-furancarbonyl chloride 
• 2756-85-6 1-aminocyclohexane carboxylic acid 
• 115951-16-1 1-tert-butoxycarbonylaminocyclohexanecarboxylic acid 
• 17191-43-4 1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid 
• 110-00-9 furan 
• 3253-43-8 Spiro<4.5>decan-2,4'-oxazolidine-2,5'-dione 

Downstream Products

• 652171-10-3 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-tert-butoxycarbonyl-3-piperidinol 
• 944281-98-5 N-[[1-[(2-Furanylcarbonyl)amino]cyclohexyl]carbonyl]-L-valine ethyl ester 
• 944281-93-0 N-[[1-[(2-furanylcarbonyl)amino]cyclohexyl]carbonyl]-L-valine 
• 944281-92-9 N-[[1-[(2-furanylcarbonyl)amino]cyclohexyl]carbonyl]-L-valinol 

Relevant academic research and scientific papers

Synthesis of sterically hindered N-acylated amino acids from N-carboxyanhydrides

Sterically hindered N-acyl, gem-disubstituted amino acids are easily prepared via the addition of organometallic reagents to N-carboxyanhydrides (NCA). The process tolerates a wide variety of functional groups and allows the synthesis of amide products not readily accessible by traditional acylation chemistry. The existence of an isocyanate intermediate was established by in situ IR spectroscopy.

Cycloalkylcarbonylamino Acid Derivative and Process For Producing The Same

Cycloalkylcarbonylamino acid derivatives, which are raw material intermediates of a novel cycloalkane carboxamide derivative that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid derivative r

Cycloalkylcarbonylamino Acid Ester Derivative and Process for Producing The Same

Cycloalkylcarbonylamino acid ester derivatives, which are raw material intermediates for a novel cycloalkane carboxamide derivative having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbony

OXAZOLONE DERIVATIVE

Novel raw material compounds are provided that are useful for producing novel cycloalkane carboxamide derivatives having cathepsin K inhibitory action. An oxazolone derivative represented by formula (I): [wherein, R1 represents a substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted phenyl group, substituted or unsubstituted naphthyl group or substituted or unsubstituted heterocyclic group, and ring A represents a saturated cyclic alkylidene group having 6 to 7 carbon atoms].

CYCLOALKANECARBOXAMIDE DERIVATIVE AND METHOD FOR PRODUCING SAME

Novel cycloalkane carboxamide derivatives having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkane carboxamide derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof: (wherein R1 and R2 represent (substituted) alkyl groups, (substituted) alkenyl groups, (substituted) alkynyl groups, (substituted) aromatic hydrocarbon groups or (substituted) heterocyclic groups, ring A represents an alkylidene group having 5 to 7 carbon atoms, and ring B represents a formyl group or a hydroxymethyl group).

1-PHENYLPIPERIDIN-3-ONE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The present invention provides 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable saltsthereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the sameas an active ingredient, and processes for the preparation thereof.