63207-03-4

Basic information

• Product Name: 1-DECYLPIPERAZINE
• Synonyms: 1-(1-DECYL)-PIPERAZINE;1-DECYLPIPERAZINE;1-N-DECYLPIPERAZINE;1-(n-Decyl)piperazine 97%;1-(Dec-1-yl)piperazine 97%;1-(Piperazin-1-yl)decane;1-(Dec-1-yl)piperazine97%
• CAS NO: 63207-03-4
• Molecular Formula: C₁₄H₃₀N₂
• Molecular Weight: 226.4
• Mol File: 63207-03-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 96 °C
• Flash Point: 90.8 °C
• Appearance: /
• Density: 0.86 g/cm³
• Vapor Pressure: 0.000872mmHg at 25°C
• Refractive Index: 1.457
• PKA: 9.26±0.10(Predicted)
• CAS DataBase Reference: 1-DECYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-DECYLPIPERAZINE(63207-03-4)
• EPA Substance Registry System: 1-DECYLPIPERAZINE(63207-03-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 63207-03-4(Hazardous Substances Data)

Usage

General Description

1-Decylpiperazine is a chemical compound with the molecular formula C14H30N2. It is a long-chain piperazine derivative that is used in various industrial applications, such as in the production of polymers and surfactants. 1-Decylpiperazine is also used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. It is a clear, colorless liquid with a faint odor and is insoluble in water but soluble in organic solvents. The compound is considered to have low toxicity and is not classified as hazardous according to standard classification systems.

InChI:InChI=1/C14H30N2/c1-2-3-4-5-6-7-8-9-12-16-13-10-15-11-14-16/h15H,2-14H2,1H3

Upstream product

• 110-85-0 piperazine 
• 112-29-8 1-bromo dodecane 
• 120-43-4 4-ethoxycarbonylpiperazine 
• 78-93-3 butanone 
• 63207-02-3 4-decyl-piperazine-1-carboxylic acid ethyl ester 
• 2050-77-3 Iododecane 

Relevant articles and documents

Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents

The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents. Herein, we report the synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill studies, their hemolytic activity against murine erythrocytes, as well as their cytotoxicity against mammalian cells. Many of these molecules exhibited broad-spectrum activity against all tested fungal strains, with excellent minimum inhibitory concentration (MIC) values against non-albicans Candida and Aspergillus strains. The most promising compounds were found to be less hemolytic than the FDA-approved antifungal agent voriconazole (VOR). Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not function by fungal membrane disruption, but instead by disruption of the ergosterol biosynthetic pathway via inhibition of the 14α-demethylase enzyme present in fungal cells.

Pentacyclo-undecane derived cyclic tetra-amines: Synthesis and evaluation as potent anti-tuberculosis agents

As part of an ongoing effort to develop highly potent anti-tuberculosis agents, fourteen pentacyclo-undecane (PCU) tetra-amine compounds were synthesized and screened for their in vitro anti-mycobacterial activity against two TB strains, H37Rv and XDR 194 [an extensively drug-resistant strain of tuberculosis]. Using the broth macrodilution method, nitrofuranylamide based compounds (6a and 6b) showed almost similar activities against the H37Rv strain of Mycobacterium tuberculosis when compared with the control drug, ethambutol. N-Geranyl piperazine PCU (8a) and trans-trans farnesyl piperazine PCU (8b) were 3.2 and 3.7 times more potent than commercially available ethambutol. Both isoprenyl PCU tetra-amine derivatives and N-decyl piperazine PCU (9a) were highly active against the XDR 194 strain of tuberculosis with MICs in the range of 0.63-3.02 μM. Cytotoxicities (IC50) of isoprenyl based compounds (8a, 8b) and compound 9a were tested on a mammalian cell line [MDBK (Madin Darby bovine kidney epithelium)] with values of 30, 24 and 25 μM respectively.

Synthesis, IR spectra and antimicrobial activity of 1,4-dialkylpiperazine dioxides

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