63207-03-4

Basic information

• Product Name: 1-DECYLPIPERAZINE
• Synonyms: 1-(1-DECYL)-PIPERAZINE;1-DECYLPIPERAZINE;1-N-DECYLPIPERAZINE;1-(n-Decyl)piperazine 97%;1-(Dec-1-yl)piperazine 97%;1-(Piperazin-1-yl)decane;1-(Dec-1-yl)piperazine97%
• CAS NO: 63207-03-4
• Molecular Formula: C₁₄H₃₀N₂
• Molecular Weight: 226.4
• Mol File: 63207-03-4.mol

Chemical Properties

• Boiling Point: 96 °C
• Flash Point: 90.8 °C
• Appearance: /
• Density: 0.86 g/cm³
• Vapor Pressure: 0.000872mmHg at 25°C
• Refractive Index: 1.457
• PKA: 9.26±0.10(Predicted)
• CAS DataBase Reference: 1-DECYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-DECYLPIPERAZINE(63207-03-4)
• EPA Substance Registry System: 1-DECYLPIPERAZINE(63207-03-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 63207-03-4(Hazardous Substances Data)

Usage

Uses

Used in Polymer Production:
1-Decylpiperazine is used as a monomer or a building block in the production of polymers, contributing to the formation of polymers with specific properties, such as enhanced solubility, stability, or reactivity.
Used in Surfactant Production:
1-Decylpiperazine is used as a component in the synthesis of surfactants, which are compounds that lower the surface tension between two liquids, a gas and a liquid, or a liquid and a solid. These surfactants find applications in various industries, including detergents, cosmetics, and pharmaceuticals.
Used in Pharmaceutical Synthesis:
1-Decylpiperazine serves as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Synthesis:
1-Decylpiperazine is also used as an intermediate in the synthesis of agrochemicals, which are chemicals used in agricultural or horticultural settings to enhance crop yield, protect plants from pests, or improve soil fertility.

InChI:InChI=1/C14H30N2/c1-2-3-4-5-6-7-8-9-12-16-13-10-15-11-14-16/h15H,2-14H2,1H3

Upstream product

• 63207-02-3 4-decyl-piperazine-1-carboxylic acid ethyl ester 
• 120-43-4 4-ethoxycarbonylpiperazine 
• 112-29-8 1-bromo dodecane 
• 78-93-3 butanone 
• 110-85-0 piperazine 
• 2050-77-3 Iododecane 

Relevant articles and documents

Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents

The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents. Herein, we report the synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill studies, their hemolytic activity against murine erythrocytes, as well as their cytotoxicity against mammalian cells. Many of these molecules exhibited broad-spectrum activity against all tested fungal strains, with excellent minimum inhibitory concentration (MIC) values against non-albicans Candida and Aspergillus strains. The most promising compounds were found to be less hemolytic than the FDA-approved antifungal agent voriconazole (VOR). Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not function by fungal membrane disruption, but instead by disruption of the ergosterol biosynthetic pathway via inhibition of the 14α-demethylase enzyme present in fungal cells.

Novel Naphthalimide Aminothiazoles as Potential Multitargeting Antimicrobial Agents

A series of novel naphthalimide aminothiazoles were developed for the first time and evaluated for their antimicrobial activity. Some prepared compounds possessed good inhibitory activity against the tested bacteria and fungi. Noticeably, the piperazine derivative 4d displayed superior antibacterial activity against MRSA and Escherichia coli with MIC values of 4 and 8 μg/mL, respectively, to reference drugs. The most active compound 4d showed low toxicity against mammalian cells with no obvious triggering of the development of bacterial resistance, and it also possessed rapid bactericidal efficacy and efficient membrane permeability. Preliminarily investigations revealed that compound 4d could not only bind with gyrase-DNA complex through hydrogen bonds but could effectively intercalate into MRSA DNA to form 4d-DNA supramolecular complex, which might be responsible for the powerful bioactivity. Further transportation behavior evaluation indicated that molecule 4d could be effectively stored and carried by human serum albumin, and the hydrophobic interactions and hydrogen bonds played important roles in the binding process.

Pentacyclo-undecane derived cyclic tetra-amines: Synthesis and evaluation as potent anti-tuberculosis agents

As part of an ongoing effort to develop highly potent anti-tuberculosis agents, fourteen pentacyclo-undecane (PCU) tetra-amine compounds were synthesized and screened for their in vitro anti-mycobacterial activity against two TB strains, H37Rv and XDR 194 [an extensively drug-resistant strain of tuberculosis]. Using the broth macrodilution method, nitrofuranylamide based compounds (6a and 6b) showed almost similar activities against the H37Rv strain of Mycobacterium tuberculosis when compared with the control drug, ethambutol. N-Geranyl piperazine PCU (8a) and trans-trans farnesyl piperazine PCU (8b) were 3.2 and 3.7 times more potent than commercially available ethambutol. Both isoprenyl PCU tetra-amine derivatives and N-decyl piperazine PCU (9a) were highly active against the XDR 194 strain of tuberculosis with MICs in the range of 0.63-3.02 μM. Cytotoxicities (IC50) of isoprenyl based compounds (8a, 8b) and compound 9a were tested on a mammalian cell line [MDBK (Madin Darby bovine kidney epithelium)] with values of 30, 24 and 25 μM respectively.

Saturated heterocyclic carboxamide derivatives

A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. STR1

3,4-Bis(4-substituted piperazinyl)-3-cyclobutene-1,2-diones and related compounds

3,4-bis(4-substituted piperazinyl)-3-cyclobutene-1,2-diones and related compounds having antiviral activity are described herein. The subject compounds can be prepared by reacting 3,4-dimethoxy-3-cyclobutene-1,2-dione with the appropriate substituted piperazine.