63228-67-1Relevant academic research and scientific papers
Transition-Metal-Free Tandem Cyclization/ N-Arylation Reaction: A Method to Access Biaryl Sultam Derivatives via a Diradical Pathway
Thorat, Vijaykumar H.,Hsieh, Jen-Chieh,Cheng, Chien-Hong
supporting information, p. 6623 - 6627 (2020/09/02)
A novel procedure for the transition-metal-free tandem cyclization/N-arylation reaction sequence of an aryne with a 1,2,3,4-benzothiatriazine-1,1-dioxide is reported. This reaction goes through the intramolecular homolytic cyclization to generate an N-H b
Dibenzo[1,2,5]thiadiazepines are non-competitive GABAA receptor antagonists
Ramirez-Martinez, Juan F.,Gonzalez-Chavez, Rodolfo,Guerrero-Alba, Raquel,Reyes-Gutierrez, Paul E.,Martinez, Roberto,Miranda-Morales, Marcela,Espinosa-Luna, Rosa,Gonzalez-Chavez, Marco M.,Barajas-Lopez, Carlos
, p. 894 - 913 (2013/03/28)
A new process for obtaining dibenzo[c,f][1,2,5]thiadiazepines (DBTDs) and their effects on GABAA receptors of guinea pig myenteric neurons are described. Synthesis of DBTD derivatives began with two commercial aromatic compounds. An azide group was obtain
Facile access to bicyclic sultams with methyl 1-sulfonylcyclopropane-l- carboxylate moieties
Rassadin, Valentin A.,Tomashevskiy, Aleksandr A.,Sokolov, Viktor V.,Ringe, Arne,Magull, Joerg,De Meijere, Armin
experimental part, p. 2635 - 2641 (2009/11/30)
N-(2,3-Dibromopropyl)- and N-(3,4-dibromobutyl)(methoxycarbonyl) methanesulfanilides upon treatment with potassium carbonate in DMF furnish, methyl 3-aryl-2,2-dioxo-2thia-3-azabicyclo[n.1.0]alkane-1.-carboxylates in yields ranging from 54 to 84% (10 examples). The starting materials were obtained by sulfonylation of N-alkenylanilines with methyl (chlorosulfonyl) acetate and. subsequent bromination. For the N-alkenylanil.in.es (10 examples, 60-77% yield) an efficient new synthesis employing a 2-nitrophenylsulfonyl substituent as a protective as well as an activating group has been developed. The 4-methoxyphenyl (PMP) group could easily be removed, from, the sultam. nitrogen atom by treatment with cerium(IV) ammonium nitrate.
Reactions of 2-(α-haloalkyl)thiiranes with nucleophilic reagents: IV. Alkylation of sulfonamides with 2-chloromethylthiirane. Synthesis and properties of 3-(arylamino)thietanes
Sokolov,Butkevich,Yuskovets,Tomashevskii,Potekhin
, p. 1023 - 1035 (2007/10/03)
Alkylation of primary and secondary sulfonamides with 2- chloromethylthiirane in the presence of alkali gives the corresponding N-(thiiran-2-ylmethyl)- and/or N-(thietan-3-yl)sulfonamides. The selectivity of the process depends on the solvent: in water, t
Benzothiadiazine compounds, and pharmaceutical composition comprising the same
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, (2008/06/13)
A compound of the formula: STR1 wherein R' is phenyl, phenyl which is substituted with halogen, lower alkyl, lower alkoxy, halo lower alkyl, lower alkylamino, lower alkylthio, phenoxy, carboxy, lower alkoxycarbonyl, carboxy lower alkyl, lower alkoxycarbon
