6323-99-5 Hazards Identification
Pictogram(s):
Signal:
Warning
GHS Hazard Statements:
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes:
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories:
Skin Irrit. 2 (100%)
Eye Irrit. 2 (100%)
STOT SE 3 (100%)
6323-99-5 Usage
Uses
Used in Pharmaceutical Industry:
2-amino-4-phosphonobutyric acid is used as a neuroprotective agent for the treatment of neurological disorders such as cerebral ischemia, epilepsy, and neurodegenerative diseases. Its ability to inhibit the activation of metabotropic glutamate receptors helps in reducing excitotoxicity, oxidative stress, and inflammation, thereby providing neuroprotection.
Used in Research Applications:
2-amino-4-phosphonobutyric acid is used as a research tool in neuroscience to study the role of glutamate receptors in synaptic transmission, neuronal excitability, and plasticity. It helps researchers understand the underlying mechanisms of various neurological disorders and develop potential therapeutic strategies.
Used in Drug Development:
2-amino-4-phosphonobutyric acid is used as a lead compound in the development of new drugs targeting metabotropic glutamate receptors for the treatment of neurological and psychiatric disorders. Its selective inhibition of these receptors offers a promising approach for the management of conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
Check Digit Verification of cas no
The CAS Registry Mumber 6323-99-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,2 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6323-99:
(6*6)+(5*3)+(4*2)+(3*3)+(2*9)+(1*9)=95
95 % 10 = 5
So 6323-99-5 is a valid CAS Registry Number.
6323-99-5Relevant academic research and scientific papers
Synthesis and characterization of intermediate and transition-state analogue inhibitors of γ-gutamyl peptide ligases
Inoue, Makoto,Hiratake, Jun,Sakata, Kanzo
, p. 2248 - 2251 (2007/10/03)
The phosphonodifluoromethyl ketone and phosphonofluoridate derivatives of L-glutamic acid were synthesized and characterized as analogues of the γ-glutamyl phosphate intermediate and the tetrahedral transition state, respectively, for the inhibition of γ-
SYNTHESE D'ACIDES ω-AMINO-ω-CARBOXY-ALKYLPHOSPHONIQUES
Aboujaoude, E. Elia,Collignon, N.,Savignac, P.,Bensoam, J.
, p. 93 - 104 (2007/10/02)
ω-Amino ω-carboxyalkylphosphonic acids 1 synthesis is reviewed.For n = 4, 5, 6 a general, efficient and inexpensive synthesis is described; acetamido(ω-bromoalkyl)malonates 12 are prepared from commercial dibromoalkanes and acetamidomalonate using the phase transfer catalysis process, then condensed with triethylphosphite through an Arbuzov reaction.An acid hydrolysis followed by purification on Dowex gives aminophosphonic acids 1 (n = 4, 5, 6) with a 70percent overall yield.The lower acid 1 (n = 2) is obtained with an identical overall yield from acetamidomalonate and 2-haloethylphosphonate using also liquid-solid phase transfer catalysis.
PREPARATION D'ACIDES AMINOCARBOXY-ALKYLPHOSPHONIQUES OPTIQUEMENT ACTIFS
Villanueva, J. M.,Collignon, N.,Guy, A.,Savignac, Ph.
, p. 1299 - 1306 (2007/10/02)
In aqueous solution ω-formylalkylphosphonates in the presence of hydrogen cyanide and (S) (-) α-methylbenzylamine give optically active aminonitriles with an enantiomeric excess of 50percent.Phosphonic aminonitriles are submitted to acid hydrolysis, then esterified and debenzylated without any epimerization.The separation is performed either with the acid or with the ester.All the operations are monitored by NMR (1H, 13C, 31P) and whenever possible, by GC.
