632328-38-2

Basic information

• Product Name: methyl (5R,7S)-3-benzyl-5-[2-(tert-butyldimethylsilyloxymethyl)phenyl]-1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]indole-7-(15-vindolinyl)-7-carboxylate
• Synonyms: methyl (5R,7S)-3-benzyl-5-[2-(tert-butyldimethylsilyloxymethyl)phenyl]-1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]indole-7-(15-vindolinyl)-7-carboxylate
• CAS NO: 632328-38-2
• Molecular Weight: 1037.38
• Mol File: 632328-38-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl (5R,7S)-3-benzyl-5-[2-(tert-butyldimethylsilyloxymethyl)phenyl]-1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]indole-7-(15-vindolinyl)-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (5R,7S)-3-benzyl-5-[2-(tert-butyldimethylsilyloxymethyl)phenyl]-1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]indole-7-(15-vindolinyl)-7-carboxylate(632328-38-2)
• EPA Substance Registry System: methyl (5R,7S)-3-benzyl-5-[2-(tert-butyldimethylsilyloxymethyl)phenyl]-1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]indole-7-(15-vindolinyl)-7-carboxylate(632328-38-2)

Safety Data

• Hazardous Substances Data: 632328-38-2(Hazardous Substances Data)

Upstream product

• 42900-89-0 3,4-dihydro-1H-2-benzopyran-3-ol 
• 4385-35-7 isochroman-3-one 
• 634597-55-0 methyl (3aRS,4RS,11bSR,6SR)-3-benzyl-4-[2-(tert-butyldimethylsilyloxymethyl)phenyl]-2,3,3a,4,5,6-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-(15-vindolinyl)-6-carboxylate 

Downstream Products

• 632328-40-6 methyl (5R,7S)-3-benzyl-5-[2-(hydroxymethyl)phenyl]-1,2,3,4,5,6,7,8-octahydro[5,4-b]indole-7-(15-vindolinyl)-7-carboxylate 

Relevant articles and documents

Syntheses and biological evaluation of vinblastine congeners.

Sixty-two congeners of vinblastine (VLB), primarily with modifications of the piperidine ring in the carbomethoxycleavamine moiety of the binary alkaloid, were synthesized and evaluated for cytotoxicity against murine L1210 leukemia and RCC-2 rat colon cancer cells, and for their ability to inhibit polymerization of microtubular protein at 10(7) M concentrations was found for L1210 inhibition by these compounds, with the most active 1000x as potent as vinblastine.