632340-57-9

Basic information

• Product Name: Benzoic acid, 4-broMo-2-(broMoMethyl)-
• Synonyms: Benzoic acid, 4-broMo-2-(broMoMethyl)-
• CAS NO: 632340-57-9
• Molecular Formula: C₈H₆Br₂O₂
• Molecular Weight: 293.94004
• Mol File: 632340-57-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 4-broMo-2-(broMoMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-broMo-2-(broMoMethyl)-(632340-57-9)
• EPA Substance Registry System: Benzoic acid, 4-broMo-2-(broMoMethyl)-(632340-57-9)

Safety Data

• Hazardous Substances Data: 632340-57-9(Hazardous Substances Data)

Upstream product

• 68837-59-2 4-bromo-2-methylbenzoic acid 

Downstream Products

• 864864-17-5 CFMTI 
• 64169-34-2 5-bromophthalide 

Relevant articles and documents

One-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2 H)-ones by DEAD-Promoted Oxidative Ugi-Wittig -Reaction Starting from Phosphonium Salt Precursors

A new one-pot synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by DEAD-promoted oxidative Ugi Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts, isocyanides, and N-aryl-1,2,3,4

Method for synthesizing roxadustat intermediate

The invention belongs to the technical field of chemical preparation, and discloses a method for synthesizing a roxadustat intermediate. The method comprises the following steps: mixing 4-bromo-2-methylbenzoic acid and a solvent to obtain a mixture 1, adding N-bromosuccinimide and an initiator into the mixture 1, performing uniform mixing to obtain a mixture 2, and performing a reaction to obtainthe roxadustat intermediate 5-bromophthalide. The method provided by the invention has the following advantages: the method for synthesizing the roxadustat intermediate provided by the invention adopts the 4-bromo-2-methylbenzoic acid as the reaction raw material, the raw material is simple and easy to obtain, the costs are low, the reaction is easy to control, and the final product 5-bromophthalide has a yield of 96.5% or more and purity of 98.5% or more.