632364-77-3Relevant academic research and scientific papers
Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase
Deng, Yongqi,Shipps Jr., Gerald W.,Wang, Tong,Popovici-Muller, Janeta,Rosner, Kristin E.,Siddiqui, M. Arshad,Duca, Jose,Cooper, Alan B.,Cable, Michael
scheme or table, p. 5363 - 5367 (2010/05/19)
A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase. A number of these compounds exhibited potent activity in enzymatic assay. The synthesis and stru
PYRAZOLO` 1,5A! PYRIMIDINE COMPOUNDS AS ANTIVIRAL AGENTS
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Page 73-74, (2010/11/30)
The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.
