632365-66-3Relevant academic research and scientific papers
Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase
Popovici-Muller, Janeta,Shipps Jr., Gerald W.,Rosner, Kristin E.,Deng, Yongqi,Wang, Tong,Curran, Patrick J.,Brown, Meredith A.,Siddiqui, M. Arshad,Cooper, Alan B.,Duca, Jose,Cable, Michael,Girijavallabhan, Viyyoor
scheme or table, p. 6331 - 6336 (2010/05/02)
The present paper describes a novel series of HCV RNA polymerase inhibitors based on a pyrazolo[1,5-a]pyrimidine scaffold bearing hydrophobic groups and an acidic functionality. Several compounds were optimized to low nanomolar potencies in a biochemical RdRp assay. SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives.
PYRAZOLO` 1,5A! PYRIMIDINE COMPOUNDS AS ANTIVIRAL AGENTS
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Page 37, (2010/11/30)
The invention relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.
