6324-13-6

Usage

Uses

Used in Organic Synthesis:
N-[2-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester serves as a key component in organic synthesis, where it is employed as a reagent to facilitate the formation of complex organic molecules. Its unique structure allows it to participate in a variety of chemical reactions, contributing to the synthesis of diverse organic compounds.
Used in Pharmaceutical Production:
As an important intermediate, N-[2-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester plays a crucial role in the development and manufacturing of pharmaceuticals. Its presence in the synthesis process aids in the creation of new drugs, potentially leading to advancements in medicine and healthcare.
Used in Agrochemical Production:
Similarly, N-[2-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester is also utilized in the production of agrochemicals, which are essential for the agricultural industry. Its involvement in the synthesis of these chemicals helps in the development of products that can improve crop yields and protect plants from pests and diseases.
However, it is important to note that N-[2-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester can be potentially toxic if inhaled or swallowed, and it may cause skin and eye irritation upon contact. Therefore, proper handling and safety measures are necessary when working with N-[2-(Ethoxycarbonylamino)phenyl]carbamic acid ethyl ester in any application.

InChI:InChI=1/C12H16N2O4/c1-3-17-11(15)13-9-7-5-6-8-10(9)14-12(16)18-4-2/h5-8H,3-4H2,1-2H3,(H,13,15)(H,14,16)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 95-54-5 1,2-diamino-benzene 
• 88-74-4 2-nitro-aniline 
• 129922-60-7 ethyl 2-(2-aminoanilino)cycloheptapyrrole-3-carboxylate 
• 64-17-5 ethanol 
• 65325-59-9 N-azidocarbonyl-anthraniloyl azide 

Downstream Products

• 53439-88-6 5-amino-1,3-dimethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 3213-79-4 N,N'-dimethyl-1,2-phenylenediamine 
• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 15719-64-9 methylammonium carbonate 

Relevant academic research and scientific papers

Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control. (Chemical Equation Presented).

Quinazoline-based multi-tyrosine kinase inhibitors: Synthesis, modeling, antitumor and antiangiogenic properties

In this work the synthesis and the biological evaluation of some novel anilinoquinazoline derivatives carrying modifications in the quinazoline scaffold and in the aniline moiety were reported. Preliminary cytotoxicity studies identified three derivatives

Titanium and zirconium complexes of robust salophan ligands. Coordination chemistry and olefin polymerization catalysis

The synthesis of [ONNO]-type robust Salophan ligands featuring tertiary nitrogen donors is described for the first time. By varying the substitution pattern on the aromatic bridge and on the phenolate rings, four ligands possessing a broad scope of electr

Nitration of ethyl carbamates of phenylenediamines and aniline

The methyl and ethyl carbamates of aniline and the diethyl dicarbamates of 1,2-, 1,3-, and 1,4-phenylenediamine were prepared. Nitration of the carbamates gave ring mono-, di-, or trinitro-derivatives in good yield. Copyright Taylor & Francis Group, LLC.

Microwave promoted solvent-free one-pot synthesis of N,N′- disubstituted urea derivatives

An efficient one-pot synthesis of N,N′-disubstituted urea derivatives from substituted anilines, ethyl chloroformate and methyl anthranilate or methyl 3-amino-2-butenoate under microwave irradiation is reported.

Ultrasound promoted 'one pot' conversion of nitrocompounds to carbamates

An efficient ultrasound promoted novel direct conversion of nitro compounds to N-(tert-butoxycarbonyl) amines and N-(ethoxycarbonylamines) is achieved using Sn-NH4Cl for the first time.

Synthesis and Some Reactions of 2-(2-Aminoanilino)cycloheptapyrroles: Leading to 5H-Cycloheptapyrrolobenzodiazepine, a Novel 20? Antiaromatic System, and Cycloheptapyrrolobenzimidazoles

2-Chlorocycloheptapyrroles reacted with o-phenylenediamine to give 2-(2-aminoanilino)cycloheptapyrroles (2a,b) in good yields.Treatment of 2a and 2b with polyphosphoric acid afforded cycloheptapyrrolobenzimidazole (4a) in good yields.Treatment of 2b with acids gave 6-(ethoxycarbonyl) derivatives (4b) of 4a and 12H-5,13-dihydrocycloheptapyrrolobenzodiazepin-12-one (5).Compound 5 was methylated with methyl iodide in the presence of DBU to give 5H-12-methoxycycloheptapyrrolobenzodiazepine, a novel 20? antiaromatic system.Treatment of 2b with sodium ethoxide gave 4b and 2H-1-(cycloheptapyrrol-2-yl)-1,3-dihydrobenzimidazol-2-one (7a).Compound 5 rearranged to 7a in the refluxing sodium ethoxide-ethanol solution.Reactions of 2a and 2b with triethyl orthoformate gave corresponding 1-(cycloheptapyrrol-2-yl)benzimidazoles.Reactions of 2a and 2b with acetic anhydride are also mentioned.