6326-75-6Relevant academic research and scientific papers
Exploration of inhibitors for diaminopimelate aminotransferase
Fan, Chenguang,Clay, Matthew D.,Deyholos, Michael K.,Vederas, John C.
experimental part, p. 2141 - 2151 (2010/05/18)
Bacteria and higher plants make l-lysine from diaminopimelic acid (DAP). In mammals l-lysine is an essential amino acid that must be acquired from the diet as the biosynthetic pathway is absent for this key constituent of proteins. Recently, ll-diaminopim
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase
Powers, Jay P.,Piper, Derek E.,Li, Yang,Mayorga, Veronica,Anzola, John,Chen, James M.,Jaen, Juan C.,Lee, Gary,Liu, Jinqian,Peterson, M. Greg,Tonn, George R.,Ye, Qiuping,Walker, Nigel P. C.,Wang, Zhulun
, p. 1034 - 1046 (2007/10/03)
Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several
