6326-87-0

Basic information

• Product Name: N-(2-hydroxyethyl)-2-phenoxyacetamide
• Synonyms: N-(2-HYDROXYETHYL)PHENOXYACETAMIDE;Einecs 228-694-2
• CAS NO: 6326-87-0
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.21512
• EINECS: 228-694-2
• Mol File: 6326-87-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 441.9 °C at 760 mmHg
• Flash Point: 221.1 °C
• Appearance: /
• Density: 1.173 g/cm³
• Vapor Pressure: 1.38E-08mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: N-(2-hydroxyethyl)-2-phenoxyacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxyethyl)-2-phenoxyacetamide(6326-87-0)
• EPA Substance Registry System: N-(2-hydroxyethyl)-2-phenoxyacetamide(6326-87-0)

Safety Data

• Hazardous Substances Data: 6326-87-0(Hazardous Substances Data)

Usage

General Description

N-(2-hydroxyethyl)-2-phenoxyacetamide, also known as phenoxyethanolamine, is a chemical compound with the molecular formula C10H13NO3. It is derived from a combination of 2-phenoxyacetic acid and ethylenediamine, and is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. N-(2-hydroxyethyl)-2-phenoxyacetamide is known for its antibacterial and preservative properties, making it a common ingredient in cosmetics, personal care products, and pharmaceuticals. It is also used as a solvent and stabilizer in various industrial processes. N-(2-hydroxyethyl)-2-phenoxyacetamide has a mild odor and is generally considered to be safe for use in low concentrations, although it may cause irritation in high doses.

InChI:InChI=1/C10H13NO3/c12-7-6-11-10(13)8-14-9-4-2-1-3-5-9/h1-5,12H,6-8H2,(H,11,13)

Upstream product

• 141-43-5 ethanolamine 
• 122-59-8 2-phenoxyacetic acid 
• 2555-49-9 phenoxyacetic acid ethyl ester 

Downstream Products

• 51816-11-6 N-(2-chloro-ethyl)-2-phenoxy-acetamide 
• 51816-22-9 2-phenoxymethyl-4,5-dihydro-oxazole 
• 122-98-5 2-Anilinoethanol 
• 70349-08-5 4,5-dihydro-2-(phenoxymethyl)-1,3-thiazole 

Relevant articles and documents

Selective Activation of Primary Carboxylic Acids by Electron-rich Triarylbismuthanes. Application to Amide and Ester Synthesis under Neutral Conditions

On being heated in benzene in the presence of tris(methoxyphenyl)bismuthanes 1b-1e, primary carboxylic acids are selectively activated to couple with amines and alcohols to produce the corresponding amides and esters in satisfactory yields, while secondary, tertiary and aromatic carboxylic acids remain unaffected. 2-Benzylmalonic acid is similarly converted into its corresponding diamides and diesters, but 2,2-dibenzylmalonic acid suffers extensive decarboxylation and, in the presence of aromatic olefins, it undergoes a novel -type cycloaddition reaction to form 4-substituted 2,2-dibenzyl-4-butanolides in low to fair yields.

Alkoxide-Accelerated Smiles Rearrangements. Synthesis of N-(2-Hydroxyethyl)anilines from N-(2-Hydroxyethyl)(aryloxy)acetamides

The first example of an alkoxide-accelerated Smiles rearrangement is reported.The rearrangement of N-(2-hydroxyethyl)(aryloxy)acetamides in dimethylformamide or tetrahydrofuran-18-crown-6 and potassium hydride produces useful yields of substituted N-(2-hydroxyethyl)anilines.