6326-87-0

Usage

Uses

Used in Pharmaceutical and Agrochemical Production:
N-(2-hydroxyethyl)-2-phenoxyacetamide is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its reactive functional groups and compatibility with a range of chemical processes.
Used in Cosmetics and Personal Care Products:
In the cosmetics and personal care industry, N-(2-hydroxyethyl)-2-phenoxyacetamide is used as a preservative to prevent the growth of bacteria and other microorganisms, ensuring the safety and shelf life of the products.
Used in Industrial Processes:
N-(2-hydroxyethyl)-2-phenoxyacetamide is utilized as a solvent and stabilizer in various industrial applications, contributing to the efficiency and stability of different processes.
Used in Antimicrobial Applications:
Due to its inherent antibacterial properties, N-(2-hydroxyethyl)-2-phenoxyacetamide is employed in applications where controlling microbial growth is essential, such as in medical equipment sterilization or in the preservation of certain food products.

InChI:InChI=1/C10H13NO3/c12-7-6-11-10(13)8-14-9-4-2-1-3-5-9/h1-5,12H,6-8H2,(H,11,13)

Upstream product

• 2555-49-9 phenoxyacetic acid ethyl ester 
• 141-43-5 ethanolamine 
• 122-59-8 2-phenoxyacetic acid 

Downstream Products

• 122-98-5 2-Anilinoethanol 
• 51816-22-9 2-phenoxymethyl-4,5-dihydro-oxazole 
• 51816-11-6 N-(2-chloro-ethyl)-2-phenoxy-acetamide 
• 70349-08-5 4,5-dihydro-2-(phenoxymethyl)-1,3-thiazole 

Relevant academic research and scientific papers

Selective Activation of Primary Carboxylic Acids by Electron-rich Triarylbismuthanes. Application to Amide and Ester Synthesis under Neutral Conditions

On being heated in benzene in the presence of tris(methoxyphenyl)bismuthanes 1b-1e, primary carboxylic acids are selectively activated to couple with amines and alcohols to produce the corresponding amides and esters in satisfactory yields, while secondary, tertiary and aromatic carboxylic acids remain unaffected. 2-Benzylmalonic acid is similarly converted into its corresponding diamides and diesters, but 2,2-dibenzylmalonic acid suffers extensive decarboxylation and, in the presence of aromatic olefins, it undergoes a novel -type cycloaddition reaction to form 4-substituted 2,2-dibenzyl-4-butanolides in low to fair yields.

Electron-rich Triarylbismuthines as Selective Condensation Reagent under Neutral Conditions. Condensation of Aliphatic Carboxylic Acids with Amines and Alcohols

On heating with amines or alcohols in the presence of tris(2-methoxyphenyl)- or tris(2,6-dimethoxyphenyl)bismuthine, carboxylic acids bearing α-hydrogen are readily converted into the corresponding amides or esters in good yields while those without α-hydrogen remain intact.

Alkoxide-Accelerated Smiles Rearrangements. Synthesis of N-(2-Hydroxyethyl)anilines from N-(2-Hydroxyethyl)(aryloxy)acetamides

The first example of an alkoxide-accelerated Smiles rearrangement is reported.The rearrangement of N-(2-hydroxyethyl)(aryloxy)acetamides in dimethylformamide or tetrahydrofuran-18-crown-6 and potassium hydride produces useful yields of substituted N-(2-hydroxyethyl)anilines.