63262-77-1Relevant academic research and scientific papers
Supramolecular control of ligand coordination and implications in hydroformylation reactions
Bellini, Rosalba,Chikkali, Samir H.,Berthon-Gelloz, Guillaume,Reek, Joost N. H.
, p. 7342 - 7345 (2011)
The coordination mode of a monodentate phosphoroamidite ligand in a rhodium complex can be switched from equatorial to axial by a unique supramolecular pseudo encapsulation (see scheme). The axial complex has higher activity and selectivity in the challenging asymmetric hydroformylation of internal alkenes. Copyright
First asymmetric synthesis of (un)substituted bridged tetrahydro-2-benzazepines
Dumoulin, David,Lebrun, Stephane,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
scheme or table, p. 195 - 201 (2010/05/02)
A new and flexible route for the asymmetric synthesis of a variety of alkylated bridged tetrahydro-2-benzazepines has been developed. The key steps are the highly diastereoselective Michael addition of metalated SAMP-hydrazones to α,β-unsaturated esters combined with cyclomethylenation/Mitsunobu coupling reactions to secure the formation of the seven-membered azaheterocycle and of the bridged unit, respectively.
Asymmetric synthesis of 3- or 4-alkyl or arylbenzo[c]azepines
Dumoulin, David,Lebrun, Stephane,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
experimental part, p. 1903 - 1911 (2010/02/27)
Two flexible routes for the stereoselective synthesis of a variety of 3- or 4-alkylated or arylated tetrahydrobenzazepines have been developed. The key steps are the highly diastereoselective metallation/alkylation reaction and 1,2-addition processes applied to stereopure SAMP hydrazones combined with a cyclomethylenation reaction.
