632628-04-7

Basic information

• Product Name: methyl 3,5-diamino-2-methyl-benzoate
• CAS NO: 632628-04-7
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.20378
• Mol File: 632628-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 3,5-diamino-2-methyl-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3,5-diamino-2-methyl-benzoate(632628-04-7)
• EPA Substance Registry System: methyl 3,5-diamino-2-methyl-benzoate(632628-04-7)

Safety Data

• Hazardous Substances Data: 632628-04-7(Hazardous Substances Data)

Upstream product

• 52090-24-1 methyl 2-methyl-3,5-dinitrobenzoate 

Downstream Products

• 632627-38-4 3-{2-[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-amino-6-methylbenzoic acid methyl ester 
• 632627-39-5 3-{2-[5-trifluoromethyl-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-amino-6-methylbenzoic acid methyl ester 
• 632627-15-7 3-{2-[5-bromo-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-amino-6-methylbenzoic acid methyl ester 
• 632627-84-0 3-{2-[5-methyl-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-amino-6-methylbenzoic acid methyl ester 
• 632626-94-9 3-{2-[5-bromo-2-(benzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-amino-6-methylbenzoic acid methyl ester 

Relevant articles and documents

1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives

Herein we describe the SAR of 1,5-biaryl pyrrole derivatives, with substituents in the 6-position of the benzoic acid moiety, as EP1 receptor antagonists. Substitution at this position was well tolerated and led to the identification of several analogues with high affinity for the EP1 receptor that displayed good efficacy in the established FCA model of inflammatory pain. Furthermore, several analogues were prepared which combined substitution at the 5- and 6-positions as well as derivatives with an aromatic ring fused to the 5- and 6-positions.