63272-29-7Relevant academic research and scientific papers
Preparation method of substituted urea compound
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Paragraph 0066-0069; 0079, (2021/06/09)
The invention provides a preparation method of a substituted urea compound. The preparation method comprises the following steps: taking a nitrogen-containing heterocyclic compound and tetrahalomethane as raw materials, carrying out illumination catalytic reaction in the presence of a catalyst and a solvent to prepare the substituted urea compound and a halogen simple substance; the preparation method is wide in raw material source, phosgene, triphosgene and the like which are high in toxicity are prevented from being adopted as raw materials, the influence of the preparation process on the environment is reduced, and the atom utilization rate of the reaction is increased; the reaction conditions are mild, the operation is simple and convenient, the environmental pollution is reduced, and the reaction cost is reduced; the product yield is high, the halogen simple substance is co-produced, the additional value is high, a large amount of waste is prevented from being generated, and the method has high atom economy and environment friendliness and is beneficial to application and popularization.
A practical synthesis of ureas from 2-aminopicolines using microwave irradiation
Charris,Dominguez,Lopez
, p. 233 - 236 (2007/10/03)
Several symemetrically disubstituted ureas are synthesized by heating of urea with 2-aminopicoline analogues under enviromentally benign conditions without any solvent in a conventional microwave oven.
