63286-29-3

Basic information

• Product Name: 2-CHLORO-6-HYDRAZINOPYRAZINE
• Synonyms: 2-CHLORO-6-HYDRAZINOPYRAZINE;(6-Chloropyrazin-2-yl)hydrazine, 2-Chloro-6-hydrazino-1,4-diazine
• CAS NO: 63286-29-3
• Molecular Formula: C₄H₅ClN₄
• Molecular Weight: 144.56
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 63286-29-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 118°
• Boiling Point: 254.8±50.0℃ (760 Torr)
• Flash Point: 107.9±30.1℃
• Appearance: /
• Density: 1.63±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.684
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-CHLORO-6-HYDRAZINOPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-HYDRAZINOPYRAZINE(63286-29-3)
• EPA Substance Registry System: 2-CHLORO-6-HYDRAZINOPYRAZINE(63286-29-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 63286-29-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-6-hydrazinopyrazine is a chemical compound with the molecular formula C4H5ClN4. It is a derivative of pyrazine and contains a chloro and hydrazino group. The compound is often used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a colorless to pale yellow solid, and it is soluble in organic solvents such as methanol and ethanol. 2-Chloro-6-hydrazinopyrazine has potential applications in the development of antitumor and antiviral medications, as well as in the production of dyes and pigments. However, it is important to handle this compound with care, as it can be toxic and harmful if not used properly.

InChI:InChI=1/C4H5ClN4/c5-3-1-7-2-4(8-3)9-6/h1-2H,6H2,(H,8,9)

Upstream product

• 4774-14-5 2,6-dichloropyrazine 

Downstream Products

• 63744-34-3 5-chloro-[1,2,4]triazolo[4,3-a]pyrazine 

Relevant articles and documents

An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials

The Open Source Malaria (OSM) consortium is developing compounds that kill the human malaria parasite, Plasmodium falciparum, by targeting PfATP4, an essential ion pump on the parasite surface. The structure of PfATP4 has not been determined. Here, we des

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

The replacement of one chemical motif with another that is broadly similar is a common method in medicinal chemistry to modulate the physical and biological properties of a molecule (i.e., bioisosterism). In recent years, bioisosteres such as cubane and bicyclo[1.1.1]pentane (BCP) have been used as highly effective phenyl mimics. Herein, we show the successful incorporation of a range of phenyl bioisosteres during the open-source optimization of an antimalarial series. Cubane (19) and closo-carborane (23) analogues exhibited improved in vitro potency against Plasmodium falciparum compared to the parent phenyl compound; however, these changes resulted in a reduction in metabolic stability; unusually, enzyme-mediated oxidation was found to take place on the cubane core. A BCP analogue (22) was found to be equipotent to its parent phenyl compound and showed significantly improved metabolic properties. While these results demonstrate the utility of these atypical bioisosteres when used in a medicinal chemistry program, the search to find a suitable bioisostere may well require the preparation of many candidates, in our case, 32 compounds.

Synthesis, bioactivity, action mode and 3D-QSAR of novel anthranilic diamide derivatives

To study the pesticide effect, action mode, structure-activity relationships (SARs) of anthranilic diamide insecticide and screen highly active pesticides, novel anthranilic diamide derivatives were synthesized. Bioassays indicated that all of the title compounds displayed 100% mortality against diamondback moth and oriental armyworm at 100 mg/L, among which 12v and 12w showed 100% insecticidal acitvity at 5 mg/L. Surprisingly compound 12w exhibited better insecticidal acitvity than commercialized chlorantraniliprole against Pyrausta nubilalis (0.1 mg/L) and Cnaphalocrocis Medinalis (2 mg/L). 3D-QSAR and SARs statistical analysis revealed that title compounds with R2 fixed as methoxy had the highest probability possessing high activity. The calcium fluorescence measurements on neurons revealed that E series compounds containing pyrazinyl may have a molecular target different from caffeine on ryanodine receptors rather than the voltage-gated calcium channel present on cytomembran.