633-01-2

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 6258-99-7 (3-amino-phenyl)-bis-(4-dimethylamino-phenyl)-methane 

Relevant academic research and scientific papers

Synthesis, characterization and application of n,n-dimethyl-n-sulfoethan ammonium tetra-chloro aluminate: A novel micro-heterogeneous catalyst for synthesis of tri-arylmethanes

A new solid catalyst was synthesized from an ionic liquid and heterogenised by changing the anion reaction. The new heterogeneous acidic catalyst was characterized by SEM images, EDS analysis, AFM images, Ft-IR, HNMR,13CNMR and Mass Spectroscop

Solvent-free synthesis of 4,4-diaminotriarylmethanes-leuco malachite materials in the presence of FePO4

A fast, efficient and versatile route for the synthesis of 4,4-diaminotriarylmethanes is reported using N,N-dimethyl aniline and aryl aldehydes in presence of FePO4 under solvent-free condition at 100°C.

Halogen-free room-temperature bronsted acidic ionic liquid [Hmim]+ HSO4- as a recyclable green "dual reagent" catalysis for the synthesis of triarylmethanes (TRAM s) ;

The halogen-free Brnsted acidic ionic liquid methylimidazolium hydrogen sulfate ([Hmim]+ HSO4-) acts as a very efficient catalyst for the one-pot, two-component Baeyer condensation of a variety of aromatic aldehydes with dimethyl or diethyl aniline at room temperature. This green reagent behaves as both catalyst and solvent; that is, it exhibits dual-reagent catalysis. The room-temperature acidic ionic liquid could be recycled several times with almost no loss in the yield of the reaction. This is the first report of the Baeyer synthesis with a halogen-free ionic liquid.

SbCl3-catalyzed one-pot synthesis of 4,4′-diamino- triarylmethanes under solvent-free conditions: Synthesis, characterization, and DFT studies

A simple, efficient, and mild procedure for a solvent-free one-step synthesis of various 4,4′-diaminotriarylmethane derivatives in the presence of antimony trichloride as catalyst is described. Triarylmethane derivatives were prepared in good to excellent yields and characterized by elemental analysis, FTIR, 1H and 13C NMR spectroscopic techniques. The structural and vibrational analysis were investigated by performing theoretical calculations at the HF and DFT levels of theory by standard 6-31Gs *, 6-31G*/B3LYP, and B3LYP/cc-pVDZ methods and good agreement was obtained between experimental and theoretical results.

ZrOCl2 catalyzed Baeyer condensation: A facile and efficient synthesis of triarylmethanes under solvent-free conditions

A facile and efficient synthesis of an array of triarylmethanes by the Baeyer condensation of different arylaldehydes carrying activated and deactivated groups and N,N-dimethyIaniline using a catalytic amount of ZrOCI2 under solvent-free microwave irradiation conditions is described. Further, the catalytic activity of ZrOCI2 is compared with traditional Lewis acid catalysts and found that this synthetic method has the advantages of excellent yields (70-96%), shorter reaction time (few minutes) and solvent-free conditions.

GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS

Compounds having Formula (I) are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of treating immune, autoimmune, inflammatory, adrenal imbalance, cognitive and behavioral diseases in a mammal.

Baeyer condensation in chloroaluminate ionic liquid

1-n-butylpyridinium chloroaluminate serves the dual purpose of a reaction medium and a Lewis acid catalyst for condensation of substituted benzaldehydes with N, N-dimethylaniline to obtain triarylmethanes (leuco bases) in good yields with significant reduction in reaction time and simplification of the workup process.

Glucocortiocoid-selective agents

Compounds having Formula I are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of treating immune, autoimmune, inflammatory, adrenal imbalance, cognitive and behavioral diseases in a mammal.

Montmorillonite clay catalysis VI: Synthesis of triarylmethanes via Baeyer condensation of aromatic aldehydes with N,N-dimethylaniline catalysed by montmorillonite K-10

Triarylmethanes are synthesized in good to excellent yield via Baeyer condensation of aromatic aldehydes with N,N-dimethylaniline catalysed by montmorillonite K 10 at 100°C in the absence of solvent.