6330-20-7Relevant academic research and scientific papers
Solvent free three-component synthesis of 2,4,5-trisubstituted-1H-pyrrol-3-ol-type Compounds from L-tryptophan: DFT-B3LYP calculations for the reaction mechanism and 3H-pyrrol-3-one?1H-pyrrol-3-ol tautomeric equilibrium
Becerra, Lili Dahiana,Coy-Barrera, Ericsson,Quiroga, Diego
, (2020/10/12)
In this paper, we describe the solvent-free three-component synthesis of 2,4,5-trisubstituted-1H-pyrrol-3-ol-type compounds from L-tryptophan. The first step of the synthetic methodology involved the esterification of L-tryptophan in excellent yields (93–98%). Equimolar mixtures of alkyl 2-aminoesters, 1,3-dicarbonyl compounds, and potassium hydroxide (0.1 eq.) were heated under solvent-free conditions. The title compounds were obtained in moderate to good yields (45%–81%). Density functional theory using “Becke, 3-parameter, Lee–Yang–Parr” correlational functional (DFT-B3LYP) calculations were performed to understand the molecular stability of the synthesized compounds and the tautomeric equilibrium from 3H-pyrrol-3-one type intermediates to 1H-pyrrol-3-ol type aromatized rings.
Preparation method of tryptophan ester hydrochloride
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Paragraph 0053-0056, (2019/12/02)
The invention discloses a preparation method of tryptophan ester hydrochloride. The preparation method comprises the following steps: 1) reacting p-toluenesulfonyl chloride with tryptophan in alcoholto obtain a tryptophan ester hydrochloride crude product; and 2) purifying the crude product to obtain the tryptophan ester hydrochloride. According to the method, the p-toluenesulfonyl chloride and the lower alcohol which are available in the market and low in price are used as raw materials, reaction conditions are easy to implement, operation is easy, the cost is greatly reduced compared with other methods, the obtained product is high in purity and the method is suitable for large-scale industrial production.
COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
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Page/Page column 45-49; 59, (2010/12/31)
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
