6330-43-4

Basic information

• Product Name: Butanethioic acid, S- (1,1-dimethylethyl) ester
• Synonyms: Butanethioic acid, S- (1,1-dimethylethyl) ester;Thiobutyric acid S-tert-butyl ester
• CAS NO: 6330-43-4
• Molecular Formula: C₈H₁₆OS
• Molecular Weight: 160.28
• Mol File: 6330-43-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 65 °C
• Boiling Point: 196.5°C at 760 mmHg
• Flash Point: 63.2°C
• Appearance: /
• Density: 0.933g/cm³
• Vapor Pressure: 0.398mmHg at 25°C
• Refractive Index: 1.46
• CAS DataBase Reference: Butanethioic acid, S- (1,1-dimethylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanethioic acid, S- (1,1-dimethylethyl) ester(6330-43-4)
• EPA Substance Registry System: Butanethioic acid, S- (1,1-dimethylethyl) ester(6330-43-4)

Safety Data

• Hazardous Substances Data: 6330-43-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H16OS/c1-5-6-7(9)10-8(2,3)4/h5-6H2,1-4H3

Upstream product

• 75-66-1 2-methylpropan-2-thiol 
• 141-75-3 butyryl chloride 
• 107-92-6 butyric acid 
• 115975-22-9 C₁₂H₁₃BrO₃ 

Downstream Products

• 110361-95-0 3-tert-Butylsulfanylcarbonyl-2-((R)-1-phenyl-ethylamino)-pentanoic acid ethyl ester 

Relevant articles and documents

A Catalyst Designed for the Enantioselective Construction of Methyl- and Alkyl-Substituted Tertiary Stereocenters

Tertiary methyl-substituted stereocenters are present in numerous biologically active natural products. Reported herein is a catalytic enantioselective method for accessing these chiral building blocks using the Mukaiyama-Michael reaction between silyl ketene thioacetals and acrolein. To enable remote enantioface control on the nucleophile, a new iminium catalyst, optimized by three-parameter tuning and by identifying substituent effects on enantioselectivity, was designed. The catalytic process allows rapid access to chiral thioesters, amides, aldehydes, and ketones bearing an α-methyl stereocenter with excellent enantioselectivities, and allowed rapid access to the C4-C13 segment of (-)-bistramide A. DFT calculations rationalized the observed sense and level of enantioselectivity.

Total synthesis of (-)-ebelactone A and B

The β-lactone enzyme inhibitors (-)-ebelactone A (1) and (-)-ebelactone B (2) have been prepared in 12 steps from diethyl ketone (4 and 3% overall yield, respectively). The synthetic strategy adopted for the ebelactones demonstrates the use of reagent- and substrate-derived stereocontrol and requires the minimal use of protecting groups. The stereocenters at C2, C3, C8, C10, and C11 were constructed using boron aldol methodology. An asymmetric syn aldol addition of diethyl ketone to 2-ethylacrolein gave adduct 8 in 86% ee, followed by a diastereoselective syn aldol reaction to give 11. Subsequently, an Ireland-Claisen rearrangement was used to relay 1,2-syn into 1,5-syn relative stereochemistry, as in 12 → 14. In the anti aldol construction of the C2-C3 bond, the use of either a propionate or butyrate thioester enolate allowed for a divergent approach from aldehyde 17 to both (-)-ebelactone A and B. Several novel analogues of ebelactone A and B were also prepared with inverted stereochemistry at C2, C3, or C12.

ACTIVATION OF MIXED CARBOXILIC α-BROMOTOLUOYL ANHYDRIDES BY SILVER TETRAFLUOROBORATE. SYNTHESIS OF ESTERS AND THIOL ESTERS

Mixed carboxylic α-bromotoluoyl anhydrides were activated by silver tetrafluoroborate through intramolecular cyclization and reacted with alcohols or thiols giving the corresponding esters or thiol esters in good yields with the elimination of phtalide.