6331-67-5

Basic information

• Product Name: 5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE
• Synonyms: TIMTEC-BB SBB011301;5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE;5-AMINO-N,N,2-TRIMETHYLBENZENESULFONAMIDE;AKOS BBS-00006473
• CAS NO: 6331-67-5
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.28
• Mol File: 6331-67-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 378.8°C at 760 mmHg
• Flash Point: 182.9°C
• Appearance: /
• Density: 1.234g/cm³
• Vapor Pressure: 6.13E-06mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE(6331-67-5)
• EPA Substance Registry System: 5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE(6331-67-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6331-67-5(Hazardous Substances Data)

Usage

General Description

5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE is a chemical compound that is commonly used as an intermediate for the synthesis of various pharmaceuticals and organic compounds. It belongs to the sulfonamide class of organic compounds and consists of a benzene ring with an amino group and three methyl groups attached to the nitrogen atom. 5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE is known for its wide range of biological activities and is utilized in the development of drugs for the treatment of various medical conditions, including cancer, bacterial infections, and inflammatory diseases. Additionally, it has been used in the research and development of new chemical compounds with potential therapeutic applications.

InChI:InChI=1/C9H14N2O2S/c1-7-4-5-8(10)6-9(7)14(12,13)11(2)3/h4-6H,10H2,1-3H3

Upstream product

• 121-02-8 2-methyl-5-nitrobenzene-1-sulfonyl chloride 

Downstream Products

• 1450730-25-2 C₁₇H₁₈N₄O₃S 
• 1450730-22-9 C₁₈H₂₃N₃O₅S 
• 1450730-19-4 C₁₇H₁₈F₃N₃O₃S 
• 1450730-16-1 V⁽⁵⁹³⁾U₀₂₆₉ 
• 1450730-13-8 C₁₆H₁₈FN₃O₃S 
• 1450730-10-5 C₁₆H₁₈FN₃O₃S 
• 1450730-07-0 C₁₇H₂₁N₃O₄S 
• 1450730-04-7 C₁₇H₂₀ClN₃O₃S 
• 1450730-01-4 C₁₆H₁₈ClN₃O₃S 
• 1450729-98-2 C₁₆H₁₉N₃O₃S 

Relevant articles and documents

Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)

G-protein coupled inwardly rectifying potassium (GIRK) channels are expressed throughout the human body and are an integral part of inhibitory signal transduction pathways. Upon binding of Gβγ subunits released from G-protein coupled receptors (GPCRs), GIRK channels open and reduce the activity of excitable cells via hyperpolarization. As such, they play a role in cardiac output, the coordination of movement and cognition. Due to their involvement in a multitude of pathways, the precision control of GIRK channels is an important endeavour. Here, we describe the development of the photoswitchable agonist LOGO (the Light-Operated GIRK channel Opener), which activates GIRK channels in the dark and is rapidly deactivated upon exposure to long wavelength UV irradiation. LOGO is the first photochromic K+ channel opener and selectively targets channels that contain the GIRK1 subunit. It can be used to optically silence action potential firing in dissociated hippocampal neurons and LOGO exhibits activity in vivo, controlling the motility of zebrafish larvae in a light-dependent fashion. We envisage that LOGO will be a valuable research tool to dissect the function of GIRK channels from other GPCR dependent signalling pathways.