6331-67-5

Usage

Uses

Used in Pharmaceutical Industry:
5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE is used as an intermediate in the synthesis of drugs for the treatment of cancer, bacterial infections, and inflammatory diseases due to its wide range of biological activities.
Used in Research and Development:
In the scientific community, 5-AMINO-2,N,N-TRIMETHYL-BENZENESULFONAMIDE is utilized for the research and development of new chemical compounds with potential therapeutic applications, contributing to the advancement of medicine and healthcare.

InChI:InChI=1/C9H14N2O2S/c1-7-4-5-8(10)6-9(7)14(12,13)11(2)3/h4-6H,10H2,1-3H3

Upstream product

• 121-02-8 2-methyl-5-nitrobenzene-1-sulfonyl chloride 

Downstream Products

• 1450729-98-2 C₁₆H₁₉N₃O₃S 
• 1450730-01-4 C₁₆H₁₈ClN₃O₃S 
• 1450730-04-7 C₁₇H₂₀ClN₃O₃S 
• 1450730-07-0 C₁₇H₂₁N₃O₄S 
• 1450730-10-5 C₁₆H₁₈FN₃O₃S 
• 1450730-13-8 C₁₆H₁₈FN₃O₃S 
• 1450730-16-1 V⁽⁵⁹³⁾U₀₂₆₉ 
• 1450730-19-4 C₁₇H₁₈F₃N₃O₃S 
• 1450730-22-9 C₁₈H₂₃N₃O₅S 
• 1450730-25-2 C₁₇H₁₈N₄O₃S 

Relevant academic research and scientific papers

Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)

G-protein coupled inwardly rectifying potassium (GIRK) channels are expressed throughout the human body and are an integral part of inhibitory signal transduction pathways. Upon binding of Gβγ subunits released from G-protein coupled receptors (GPCRs), GIRK channels open and reduce the activity of excitable cells via hyperpolarization. As such, they play a role in cardiac output, the coordination of movement and cognition. Due to their involvement in a multitude of pathways, the precision control of GIRK channels is an important endeavour. Here, we describe the development of the photoswitchable agonist LOGO (the Light-Operated GIRK channel Opener), which activates GIRK channels in the dark and is rapidly deactivated upon exposure to long wavelength UV irradiation. LOGO is the first photochromic K+ channel opener and selectively targets channels that contain the GIRK1 subunit. It can be used to optically silence action potential firing in dissociated hippocampal neurons and LOGO exhibits activity in vivo, controlling the motility of zebrafish larvae in a light-dependent fashion. We envisage that LOGO will be a valuable research tool to dissect the function of GIRK channels from other GPCR dependent signalling pathways.

Triazole compounds that modulate Hsp90 activity

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.