63314-60-3Relevant academic research and scientific papers
Design and Synthesis of 1,3,4-Thiadiazole Derivatives as Novel Anticancer and Antitubercular Agents
Chandra Sekhar,Venkata Rao,Tejeswara Rao,Lav Kumar,Jha, Anjali
, p. 770 - 779 (2019/06/05)
A series of novel 5-phenyl-substituted 1,3,4-thiadiazole-2-amines were designed, synthesized, and screened for their antitumor and antitubercular activities. The target compounds were synthesized starting from isocyanates and acid hydrazides by convention
Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate
Yang, Seung-Ju,Lee, Seok-Hyeong,Kwak, Hyun-Jung,Gong, Young-Dae
, p. 438 - 444 (2013/04/10)
A regioselective, reagent-based method for the cyclization reaction of 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeletons is described. The thiosemicarbazide intermediate 3 was reacted with EDC·HCl in DMSO or p-TsCl, triethylamine in N-
The reactions of cyclization of thiosemicarbazide derivatives to 1,2,4-triazole or 1,3,4-thiadiazole system
Dobosz, Maria,Pitucha, Monika,Wujec, Monika
, p. 31 - 38 (2007/10/03)
In the reaction of hydrazide of formic, nicotinic and benzoic acid with isothiocyanates were obtained the respective thiosemicarbazide derivatives [I-XII]. Further cyclization with 2% NaOH solution led to formation of derivatives Δ2-1,2,4-triaz
