63320-66-1

Upstream product

• 82837-97-6 dimethyl trans(1,2),trans(2,3)-6,7-dimethoxy-1-(3,4-dimethoxyphenyl)-1,3,4-tetrahydronaphthalene-2,3-dicarboxylate 
• 79150-37-1 2,3-Dimethoxy-7-methyl-naphthalin-6-carbonsaeure-ethylester 
• 114839-36-0 (1R,2S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-3-methoxymethyl-1,2-dihydro-naphthalene-2-carboxylic acid (1S,2S)-2-amino-3-methoxy-1-methyl-propyl ester; compound with trifluoro-acetic acid 
• 114839-34-8 (4R,5R)-2-[(1R,2S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-3-methoxymethyl-1,2-dihydro-naphthalen-2-yl]-4-methoxymethyl-5-methyl-4,5-dihydro-oxazole 
• 114839-33-7 L-trans-threonine oxazoline 
• 114839-37-1 [(1R,2S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-3-methoxymethyl-1,2-dihydro-naphthalen-2-yl]-methanol 
• 114839-30-4 2-(ethoxycarbonyl)-3-(methoxymethyl)-6,7-dimethoxynaphthalene 
• 114839-29-1 2-(ethoxycarbonyl)-3-(bromomethyl)-6,7-dimethoxynaphthalene 
• 80245-51-8 4-lithio-1,2-dimethoxybenzene 
• 2859-78-1 4-Bromoveratrole 
• 63320-64-9 (-)-demethylphyltetralin 
• 74-88-4 methyl iodide 
• 82792-84-5 (3,4-Dimethoxy-phenyl)-(2-hydroxymethyl-4,5-dimethoxy-phenyl)-methanol 
• 82792-86-7 1-(3,4-Dimethoxy-phenyl)-5,6-dimethoxy-1,3-dihydro-benzo[c]thiophene 

Downstream Products

• 79606-73-8 4-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-3-methoxymethyl-naphthalene-2-carbaldehyde 

Relevant academic research and scientific papers

Oxidative aryl-aryl, aryl-benzyl coupling of lignans-reactions of phyllanthin and haloderivatives with TTFA, DDQ, Li/THF)))): Synthesis of dibenzocyclooctadiene system and phyltetralin

Treatment of phyllanthin (1) with TTFA in TFA gives dibenzocyclooctadiene (2) and phyltetralin (3). Treatment of (1) with DDQ in TFA also affords (2) while with DDQ in acetic acid gives 1-phenylnaphthalenic lignan (4). Synthesis of halophyllanthins (5,6,7) and its Ullmann reaction in ultrasonic condition affords reductive dehalogenated product (1) instead of (2). Treatment of (1) with POCl3 in TCA gives (+) 3,4-diveratryltetrahydrofuran (8) and its conversion to (9) also reported. Treatment of (5) with TTFA/TFA gives (9).

The Synthesis of Lignans and Related Structures using Quinodimethanes and Isobenzofurans: Approaches to the Podophyllins

Novel routes to 1-aryl-5,6-dialkoxy-1,3-dihydrobenzothiophene 2,2-dioxides (13) and to the corresponding benzofuran (8) have been developed; these species yield quinodimethanes (12) via thermal extrusion of SO2 and isobenzofurans (5c) in an acid-cat

The Preparation of Lignans via Intermolecular Cycloadditions with Quinodimethanes

Certain lignans can be prepared using, as the key step, a thermal reaction between 1-(aryl)-1,3-dihydro-5,6-dialkoxy-benzothiophen 2,2-dioxides and dienophiles.

Synthesis of Aryltetralin and Dibenzylbutyrolactone Lignans: (+/-)-Lintetralin, (+/-)-Phyltetralin, and (+/-)-Kusunokinin

Application of a general synthetic pathway for aryltetralin and dibenzylbutyrolactone lignans, starting from the lithium enolate of 3-(3,4-dimethoxybenzyl)butyrolactone (1) led to syntheses of (+/-)-lintetralin (4), (+/-)-phyltetralin (5), (+/-)-isogalcat

STRUCTURE AND SYNTHESYS OF HYPOPHYLLANTHIN, NIRTETRALIN, PHYLTETRALIN AND LINTETRALIN

Structures propounded for the four aryltetralin lignan constituents isolated from Phyllanthus niruri Linn. are confirmed by syntheses of their (+/-)-forms.