63320-88-7Relevant academic research and scientific papers
Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors
Jha, Amitabh,Duffield, Katherine M.,Ness, Matthew R.,Ravoori, Sujatha,Andrews, Gabrielle,Bhullar, Khushwant S.,Rupasinghe, H.P. Vasantha,Balzarini, Jan
, p. 6404 - 6417 (2015)
Three series of novel 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones, designed as simplified analogs of curcumin with maleic diamide tether, were synthesized and bioevaluated. These compounds displayed potent cytotoxicity tow
