63328-13-2 Usage
Uses
Used in Pharmaceutical Synthesis:
(R)-2-benzylpyrrolidine is used as a building block for the development of pharmaceutical and biologically active compounds, leveraging its chiral nature and potential pharmacological properties to create novel therapeutic agents.
Used in Chiral Auxiliary Applications:
In the field of organic chemistry, (R)-2-benzylpyrrolidine is employed as a chiral auxiliary in stereoselective synthesis reactions, aiding in the creation of enantiomerically pure compounds with desired stereochemistry.
Used in Research and Development:
(R)-2-benzylpyrrolidine serves as a valuable compound in research and development, particularly in the fields of medicinal chemistry and drug discovery, where its unique properties can be harnessed to design and synthesize new molecules with specific biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 63328-13-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,3,2 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 63328-13:
(7*6)+(6*3)+(5*3)+(4*2)+(3*8)+(2*1)+(1*3)=112
112 % 10 = 2
So 63328-13-2 is a valid CAS Registry Number.
63328-13-2Relevant academic research and scientific papers
A rapid and general method for the asymmetric synthesis of 2-substituted pyrrolidines using tert-butanesulfinamide
Brinner, Kristin M.,Ellman, Jonathan A.
, p. 2109 - 2113 (2007/10/03)
A new method for the asymmetric synthesis of 2-substituted pyrrolidines in three steps from commercially available starting materials is described. Addition of the Grignard reagent prepared from 2-(2-bromoethyl)-1,3-dioxane to N-tert-butanesulfinyl aldimines proceeds in high yields and with good diastereoselectivities. The sulfinamide products are then cleanly converted into pyrrolidines in one step. The Royal Society of Chemistry 2005.
Enantioselective synthesis of 2-substituted pyrrolidines from 4-hydroxynitriles. Application to the synthesis of the dopamine agonist RS-59022
Gooding,Bansal
, p. 1155 - 1166 (2007/10/02)
Two novel routes to optically active 4-hydroxynitriles and the subsequent cyclization to 2-substituted pyrrolidines are described. The methodology is applied to the synthesis of the key intermediate used in the synthesis of the dopamine agonist RS-59022. Unusual selectivity in the CBS reduction of 4-oxonitriles is explained through structural and mechanistic analysis.
