6333-37-5

Basic information

• Product Name: N-(2,4-Dichlorophenyl)carbamic acid ethyl ester
• Synonyms: 2,4-Dichlorophenylurethane;N-(2,4-Dichlorophenyl)carbamic acid ethyl ester
• CAS NO: 6333-37-5
• Molecular Formula: C₉H₉Cl₂NO₂
• Molecular Weight: 234.0793
• Mol File: 6333-37-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 265.3°Cat760mmHg
• Flash Point: 114.2°C
• Appearance: /
• Density: 1.382g/cm³
• Vapor Pressure: 0.00924mmHg at 25°C
• Refractive Index: 1.584
• PKA: 12.06±0.70(Predicted)
• CAS DataBase Reference: N-(2,4-Dichlorophenyl)carbamic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-Dichlorophenyl)carbamic acid ethyl ester(6333-37-5)
• EPA Substance Registry System: N-(2,4-Dichlorophenyl)carbamic acid ethyl ester(6333-37-5)

Safety Data

• Hazardous Substances Data: 6333-37-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H9Cl2NO2/c1-2-14-9(13)12-8-4-3-6(10)5-7(8)11/h3-5H,2H2,1H3,(H,12,13)

Upstream product

• 51-79-6 urethane 
• 541-73-1 1,3-Dichlorobenzene 
• 2621-80-9 ethyl p-chlorophenylcarbamate 
• 541-41-3 chloroformic acid ethyl ester 
• 554-00-7 2,4-Dichloroaniline 

Downstream Products

• 1356965-26-8 (5RS)-5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-N-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide 
• 1356965-18-8 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(2,4-dichlorophenyl)hydrazinecarboxamide 
• 732223-04-0 N-(2,4-dichlorophenyl)hydrazinecarboxamide 
• 145858-62-4 5-tert-Butyl-3-(2,4-dichloro-phenyl)-3H-oxazol-2-one 

Relevant articles and documents

Electrophotocatalytic C?H Heterofunctionalization of Arenes

The electrophotocatalytic heterofunctionalization of arenes is described. Using 2,3-dichloro-5,6-dicyanoquinone (DDQ) under a mild electrochemical potential with visible-light irradiation, arenes undergo oxidant-free hydroxylation, alkoxylation, and amination with high chemoselectivity. In addition to batch reactions, an electrophotocatalytic recirculating flow process is demonstrated, enabling the conversion of benzene to phenol on a gram scale.

Design and synthesis of novel stiripentol analogues as potential anticonvulsants

A series of stiripentol (STP) analogues namely, 2-[(1E)-1-(1,3-benzodioxol- 5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(aryl/H)hydrazinecarboxamides 7a-h, (±)-(5RS)-N-(aryl/H)-(1,3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazole-1-carboxamides (±)-8a-h, and (±)-[(5RS)-(1, 3-benzodioxol-5-yl)-3-tert-butyl-4,5-dihydro-1H-pyrazol-1-yl](aryl)methanones (±)-13a-f was synthesized by adopting appropriate synthetic routes and was pharmacologically evaluated in the preliminary anticonvulsant screens. The selected bioactive new chemical entities were subjected to ED50 determination and neurotoxicity evaluation. The most active congeners are 7h in MES screen and (±)-13b in scPTZ screen which displayed ED50 values of 87 and 110 mg/kg, respectively, as compared to that of STP (ED 50 = 277.7 and 115 mg/kg in MES and scPTZ, respectively).