6333-84-2Relevant academic research and scientific papers
In-depth examination of the pterolactams behaviour in Lewis/Br?nsted acid catalysis environment: Total isolation of the reaction products
Dumitriu, Gina-Mirabela,B?cu, Elena,Rigo, Beno?t,Moncol, Ján,Da?ch, Adam,Ghinet, Alina
, (2021/01/20)
To gain some insights on the amidoalkylation process, we were interested in studying the product distribution when pterolactam was exposed to acids. The reactivity of pterolactam and its N-aryl derivatives towards TMSOTf or TfOH has been carefully examine
Continuous-flow oxidative homocouplings without auxiliary substances: Exploiting a solid base catalyst
?tv?s, Sándor B.,Georgiádes, ádám,Mészáros, Rebeka,Kis, Koppány,Pálinkó, István,Fül?p, Ferenc
, p. 90 - 99 (2017/03/15)
The catalytic oxidative dimerization of aromatic amines and acetylenes is of outstanding synthetic importance among homocoupling reactions. Both transformations necessitate the use of extraneous bases and ligands, which contains significant disadvantages as concerns environmental impacts and process costs. We exploited the inherent basic character of a copper-containing layered double hydroxide to facilitate the catalytic homocouplings of alkynes and aniline derivatives without the need for any auxiliary substances. The reactions were studied in a continuous-flow system to achieve extended parameter spaces for chemical intensification, and also to avoid undesired reaction pathways by means of strategic control over the residence time. Valuable 1,4-disubstituted 1,3-diynes and diversely substituted aromatic azo compounds were achieved chemoselectively in excellent yields and in short process times even on preparative scales.
