633305-75-6

Upstream product

• 633305-74-5 N-(2,4-dimethoxy-phenyl)-N-{1-[3-(4-methyl-piperazin-1-yl)-4-oxo-3,4-dihydro-quinazolin-2-yl]-ethyl}-2,4-dinitro-benzenesulfonamide 
• 633305-72-3 2-(1-hydroxy-ethyl)-3-(4-methyl-piperazin-1-yl)-3H-quinazolin-4-one 
• 770743-64-1 2-((R)-2-Acetoxy-propionylamino)-benzoic acid 
• 6928-85-4 N-amino-N'-methylpiperazine 

Relevant academic research and scientific papers

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

The discovery of a series of quinazolinone-based fungal efflux pump inhibitors by high-throughput screening for potentiation of fluconazole in C. albicans is described. Attempts to improve the aqueous solubility of screening hits led to the discovery of an analog with greatly improved physical properties and activity against clinically-relevant Candida spp.

Fungal efflux pump inhibitors

This invention relates to compounds that are efflux pump inhibitors and therefore are useful as potentiators of anti-fungal agents for the treatment of infections caused by fungi that employ an efflux pump resistance mechanism.